Interspecies Organogenesis for Human Transplantation
| Autor: | Mercedes Ruiz-Estévez, Christopher J. Sipe, Wei Shou Hu, Ling Li, Nikolas G. Toman, Andrew W. Grande, Clairice Pearce, Daniel F. Carlson, Ann M. Parr, Timothy O'Brien, Georgette Danczyk, James R. Dutton, Joseph P. Voth, Walter C. Low, Maxim C.-J. Cheeran, Zachary D. Miller, Angela Panoskaltsis-Mortari, Clifford J. Steer, Venkatramana D. Krishna, Andrew T. Crane, Perry B. Hackett, Wei Cheng Lu, Hui Xie, Atsushi Asakura, Rajagopal N. Aravalli, Maple Shiao |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Pluripotent Stem Cells
Candidate gene Organogenesis Biomedical Engineering Reviews Biology Regenerative medicine Animals Genetically Modified 03 medical and health sciences 0302 clinical medicine Genome editing medicine Animals Humans Blastocyst blastocyst complementation Gene development 030304 developmental biology 0303 health sciences gene editing Gene Expression Regulation Developmental Cell Biology Organ Transplantation 3. Good health Cell biology Transplantation Complementation medicine.anatomical_structure organ bioengineering Medicine Stem cell 030217 neurology & neurosurgery transplantation |
| Zdroj: | Cell Transplantation Cell Transplantation, Vol 28 (2019) |
| ISSN: | 1555-3892 0963-6897 |
| Popis: | Blastocyst complementation combined with gene editing is an emerging approach in the field of regenerative medicine that could potentially solve the worldwide problem of organ shortages for transplantation. In theory, blastocyst complementation can generate fully functional human organs or tissues, grown within genetically engineered livestock animals. Targeted deletion of a specific gene(s) using gene editing to cause deficiencies in organ development can open a niche for human stem cells to occupy, thus generating human tissues. Within this review, we will focus on the pancreas, liver, heart, kidney, lung, and skeletal muscle, as well as cells of the immune and nervous systems. Within each of these organ systems, we identify and discuss (i) the common causes of organ failure; (ii) the current state of regenerative therapies; and (iii) the candidate genes to knockout and enable specific exogenous organ development via the use of blastocyst complementation. We also highlight some of the current barriers limiting the success of blastocyst complementation. |
| Databáze: | OpenAIRE |
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