Separations of Carbohydrates with Noncovalent Shift Reagents by Frequency-Modulated Ion Mobility-Orbitrap Mass Spectrometry

Autor:	Facundo M. Fernández, Charles L. Liotta, Ramanarayanan Krishnamurthy, Brian H. Clowers, Kristin R. McKenna
Rok vydání:	2021
Předmět:	Spectrum analyzer Resolution (mass spectrometry) Atmospheric pressure Chemistry Analytical chemistry Orbitrap Mass spectrometry Sweep frequency response analysis Ion law.invention Structural Biology law Reagent Spectroscopy
Zdroj:	Journal of the American Society for Mass Spectrometry. 32:2472-2480
ISSN:	1879-1123 1044-0305
DOI:	10.1021/jasms.1c00184
Popis:	An increased focus on characterizing the structural heterogeneity of carbohydrates has been driven by their many significant roles in extant life and potential roles in chemical evolution and the origin of life. In this work, multiplexed drift tube ion mobility-Orbitrap mass spectrometry methods were developed to analyze mixtures of disaccharides modified with noncovalent shift reagents. Since traditional coupling of atmospheric pressure drift tube ion mobility cells with Orbitrap mass analyzers suffers from low duty cycles (
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::296965f0eb02e8ab412b62ac4f8af760 https://doi.org/10.1021/jasms.1c00184 Zobrazit plný text záznamu