The kinetics of inorganic phosphate excretion in the acidotic rabbit during intravenous phosphate loading: a pseudo-ruminant model
| Autor: | Daniel J. O’Donovan, Patrick A Walsh |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Urinary system 030232 urology & nephrology Renal function lcsh:Medicine Kidney Transport maximum Article Phosphates Excretion 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine medicine Animals lcsh:Science Saliva Multidisciplinary Chemistry Reabsorption Monogastric lcsh:R Hindgut Phosphate Gastrointestinal Tract Kinetics 030104 developmental biology Endocrinology Nephrology lcsh:Q Administration Intravenous Rabbits |
| Zdroj: | Scientific Reports Scientific Reports, Vol 10, Iss 1, Pp 1-8 (2020) |
| ISSN: | 2045-2322 |
| Popis: | The rabbit is a much-used experimental animal in renal tubule physiology studies. Although a monogastric mammal, the rabbit is a known hindgut fermenter. That ruminant species excrete inorganic phosphate (Pi) mainly through the digestive system while non-ruminants eliminate surplus phosphate primarily through the renal system are acknowledged facts. To understand phosphate homeostasis in the acidotic rabbit, anaesthetized animals were infused with hydrochloric acid, after which they underwent intravenous phosphate loading. Biofluids were collected during the infusion process for analysis. Plasma Pi increased (7.9 ± 1.7 mmoles.Litre−1 (N = 5) vs 2.2 ± 0.4 mmoles.Litre−1 (N = 10) pre-infusion, (p −1 (N = 9), pre-infusion, p −1, while a reading of 23.2 µmol.min−1.Kg.0.75 was obtained for the transport maximum for Pi (TmPi). The high reabsorptivity of the rabbit nephrons coupled with possibly a high secretory capacity of the salivary glands for Pi, may constitute a unique physiological mechanism that ensures the rabbit hindgut receives adequate phosphate to regulate caecal pH in favour of the resident metabolically - active microbiota. The handling of Pi by the rabbit is in keeping with the description of this animal as a monogastric, pseudo-ruminant herbivore. |
| Databáze: | OpenAIRE |
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