Sentinel lymph node biopsy technique and multifocal breast cancer - The Aarhus experience
| Autor: | Anders Lernevall, Anders Husted Madsen, Anne-Mette Iversen, Peer Christiansen, Line Buhl, Jens Peter Garne, Mette Cathrine Lauridsen |
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| Jazyk: | angličtina |
| Rok vydání: | 2007 |
| Předmět: |
medicine.medical_specialty
Multifocal breast cancer Sentinel lymph node Breast Neoplasms Sensitivity and Specificity Neoplasms Multiple Primary Breast cancer Biopsy medicine Humans Mammography Radiology Nuclear Medicine and imaging Prospective cohort study Lymph node medicine.diagnostic_test Sentinel Lymph Node Biopsy business.industry General surgery Hematology General Medicine medicine.disease Axilla medicine.anatomical_structure Oncology Lymphatic Metastasis Female Radiology business |
| Zdroj: | Madsen, A H, Lauridsen, M C, Garne, J P, Iversen, A, Lernevall, A, Buhl, L & Christiansen, P M 2007, ' Sentinel lymph node biopsy technique and multifocal breast cancer-The Aarhus experience ', Acta Oncologica, vol. 46, no. 5, pp. 691-696 . https://doi.org/10.1080/02841860600996454 Madsen, A H, Lauridsen, M C, Garne, J P, Iversen, A, Lernevall, A, Buhl, L & Christiansen, P 2007, ' Sentinel lymph node biopsy technique and multifocal breast cancer--the Aarhus experience. ', Acta Oncologica, vol. 46, no. 5, pp. 691-6 . https://doi.org/10.1080/02841860600996454 |
| Popis: | Staging of the axilla in breast cancer is essential because lymph node status is the most important prognostic factor [1]. On patients with unifocal breast cancer the sentinel lymph node biopsy technique (SLNB) is a reliable tool to detect lymph node metastases and perhaps even more importantly to identify patients without metastases [2 6]. Patients without metastases can avoid a total axillary dissection and the related complications [7 12]. The method has rapidly been implemented as standard procedure despite there being no documented evidence of a beneficial effect on overall survival and relapse rate. However, trials with the aim of investigating these important issues are ongoing [13 15]. Compared with the numerous studies of the SLNB on patients with unifocal breast cancer relatively few validation studies have been made on patients having multifocal or multicentric tumors (Table I). Unfortunately, the published works are not comparable. This is mainly because different definitions of multifocal and multicentric breast cancer are used, but also that the inclusion criteria used in the studies are not uniform. Few of the studies have been performed as prospective studies, and with the only aim to investigate the methods reliability. Despite these facts, it is now generally accepted, that the method works among patients with more than one tumor in the same breast [16]. The aim of the present study was to validate the use of SLNB in patients, who preoperatively had been diagnosed with more than one tumor on either mammography and/or ultrasonography. |
| Databáze: | OpenAIRE |
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