COVID-19 progression in kidney transplant recipients: a single-center case series

Autor: Mohammad Keykhaei, Ensieh Zivari, Effat Razeghi, Hormat Rahimzadeh, Ensieh Sadat Mansouri
Rok vydání: 2021
Předmět:
Adult
Male
Nephrology
medicine.medical_specialty
Indoles
Prednisolone
medicine.medical_treatment
030232 urology & nephrology
Case Report
Iran
030204 cardiovascular system & hematology
Antiviral Agents
law.invention
Antimalarials
03 medical and health sciences
AKI
0302 clinical medicine
Risk Factors
law
Internal medicine
Outcome Assessment
Health Care
Humans
Medicine
Hospital Mortality
Risk factor
Kidney transplant
Glucocorticoids
Kidney transplantation
SARS-CoV-2
business.industry
Acute kidney injury
COVID-19
Respiratory infection
Immunosuppression
General Medicine
Acute Kidney Injury
Middle Aged
medicine.disease
Kidney Transplantation
Intensive care unit
Transplant Recipients
Intensive Care Units
Disease Progression
Female
business
Immunosuppressive Agents
Hydroxychloroquine
Kidney disease
Zdroj: CEN Case Reports
ISSN: 2192-4449
Popis: The novel coronavirus disease 2019 (COVID-19) is a respiratory infection that has received much attention due to its rapid expansion. Currently, it has been revealed that patients with underlying disease, especially those with kidney disease are more prone to develop complications. Some studies associate kidney transplantation as a risk factor for COVID-19 progression; however, epidemiologic data that demonstrate this are amazingly rare. Considering the importance of the topic, we report on six kidney transplant recipients (median age 47 [41–55]) with confirmed or clinically suspected COVID-19. The most common admission presentations were fever (83.3%), dyspnea, and myalgia. At baseline, immunosuppressive therapy was ceased, prednisolone dose was increased, and all patients received antiviral treatment including hydroxychloroquine and umifenovir. After a median follow-up of 11.5 days from admission, six patients (100%) developed acute kidney injury (AKI), 50% required intensive care unit (ICU) admission, and two patients (33.3%) deceased as a result of deterioration in respiratory status. Overall, these findings demonstrate that respiratory involvement may be a risk indicator of in-hospital mortality in kidney recipients with COVID-19. In addition, AKI development in kidney recipients with COVID-19 is of utmost importance given the higher AKI occurrence in these patients compared with others. Therefore, more intensive attention should be paid to kidney transplant recipients with COVID-19.
Databáze: OpenAIRE
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