A perspective on copper and liver disease in the dog
| Autor: | Larry P. Thornburg |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty Pathology Cirrhosis 040301 veterinary sciences Copper metabolism chemistry.chemical_element Biology 0403 veterinary science 03 medical and health sciences Liver disease Dogs Internal medicine medicine Animals Dog Diseases Hepatitis General Veterinary Liver Diseases 04 agricultural and veterinary sciences medicine.disease Copper Pedigree 030104 developmental biology Endocrinology chemistry Toxicity Female Copper deficiency Intracellular |
| Zdroj: | Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc. 12(2) |
| ISSN: | 1040-6387 |
| Popis: | Copper is a ubiquitous trace metal necessary for normal function of a variety of cellular proteins. Intracellular copper metabolism is complex, and only a few of the proteins/genes involved are known. Copper deficiency does not appear to be a clinical problem in dogs. Excess copper accumulation in the liver as a cause of hepatitis and cirrhosis was first demonstrated among Bedlington terriers. Subsequently, copper accumulation in the liver has been shown to occur in several other breeds of dogs. Excess hepatic copper has been found in dogs with normal liver histology, dogs with hepatitis, and dogs with end stage cirrhosis. Evidence is accumulating that copper is a cause of liver disease in breeds of dogs other than Bedlington terriers. Moreover, as more data are accumulated, the copper storage disease appears to have characteristics that are very similar among all of the affected breeds. |
| Databáze: | OpenAIRE |
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