Three new bioactive flavonoid glycosides from Viscum album
| Autor: | Mengyang Hou, Meng-Qing Li, Yahui Wei, Duo Cao, Cui-Hua Li, Gao Jing, Jia-Kun Dai, Zheng-Liang Sun, Na Fan |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Cell Survival
Viscum album Flavonoid Antineoplastic Agents 01 natural sciences HeLa 03 medical and health sciences 0302 clinical medicine Cell Line Tumor Drug Discovery Humans Glycosides Cytotoxicity IC50 Flavonoids chemistry.chemical_classification Molecular Structure Flavonoid glycosides biology Traditional medicine Plant Extracts 010405 organic chemistry Glycoside General Medicine Plant Components Aerial biology.organism_classification 0104 chemical sciences Complementary and alternative medicine chemistry 030220 oncology & carcinogenesis |
| Zdroj: | Chinese Journal of Natural Medicines. 17:545-550 |
| ISSN: | 1875-5364 |
| DOI: | 10.1016/s1875-5364(19)30076-7 |
| Popis: | Two new flavonoid glycosides, named viscumneoside XII (1), and viscumneoside XIII (2); a new dihydrogen flavonoid glycoside product named viscumneoside XIV (3), were isolated from the aerial part of Viscum album, along with seven known compounds (4-10). Their structures were identified by analysis of spectroscopic data. In addition, cytotoxicity assay showed that 1, 2 and 3 possessed significant inhibitory activities against C6, A549 and MDA-MB-231 (the inhibition rate arrived about 50%, 70% and 74% respectively with IC50 ≤ 60.00 μmol·L-1), while the inhibition of TF-1 and Hela was not significant. |
| Databáze: | OpenAIRE |
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