Effect of skilled and unskilled training on nerve regeneration and functional recovery
| Autor: | Franklin Panato Back, Jocemar Ilha, Carlos Alexandre Netto, Erica do Espirito Santo Hermel, Matilde Achaval, Stella Maris Michaelsen, Aline de Souza Pagnussat |
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| Rok vydání: | 2012 |
| Předmět: |
Male
medicine.medical_specialty Recuperação de função fisiológica Physiology Short Communication Immunology Nervo mediano Biophysics Median nerve Biochemistry Peripheral Nerve Injuries Physical Conditioning Animal Nerve morphometry Animals Medicine Rats Wistar General Pharmacology Toxicology and Pharmaceutics Treadmill Ulnar nerve business.industry General Neuroscience Nervo ulnar Functional recovery Recovery of Function Cell Biology General Medicine medicine.disease Sciatic Nerve Nerve Regeneration Rats Surgery Electrophysiology Treatment Outcome medicine.anatomical_structure Brachial plexus injury Peripheral nerve injury Anesthesia Sciatic nerve Forelimb Traumatismos dos nervos periféricos business |
| Zdroj: | Brazilian Journal of Medical and Biological Research Repositório Institucional da UFRGS Universidade Federal do Rio Grande do Sul (UFRGS) instacron:UFRGS |
| ISSN: | 0100-879X |
| DOI: | 10.1590/s0100-879x2012007500084 |
| Popis: | The most disabling aspect of human peripheral nerve injuries, the majority of which affect the upper limbs, is the loss of skilled hand movements. Activity-induced morphological and electrophysiological remodeling of the neuromuscular junction has been shown to influence nerve repair and functional recovery. In the current study, we determined the effects of two different treatments on the functional and morphological recovery after median and ulnar nerve injury. Adult Wistar male rats weighing 280 to 330 g at the time of surgery (N = 8-10 animals/group) were submitted to nerve crush and 1 week later began a 3-week course of motor rehabilitation involving either “skilled” (reaching for small food pellets) or “unskilled” (walking on a motorized treadmill) training. During this period, functional recovery was monitored weekly using staircase and cylinder tests. Histological and morphometric nerve analyses were used to assess nerve regeneration at the end of treatment. The functional evaluation demonstrated benefits of both tasks, but found no difference between them (P > 0.05). The unskilled training, however, induced a greater degree of nerve regeneration as evidenced by histological measurement (P < 0.05). These data provide evidence that both of the forelimb training tasks used in this study can accelerate functional recovery following brachial plexus injury. |
| Databáze: | OpenAIRE |
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