COVID-19 and Respiratory System Disorders: Current Knowledge, Future Clinical and Translational Research Questions

Autor: Annemijn H. Jonkman, Shari B. Brosnahan, Matthias C. Kugler, David A. Kaufman, John S. Munger
Jazyk: angličtina
Rok vydání: 2020
Předmět:
0301 basic medicine
Disease
030204 cardiovascular system & hematology
Translational Research
Biomedical
0302 clinical medicine
Risk Factors
Respiratory system
Lung
Respiratory Distress Syndrome
Respiration
Respiratory disease
Venous Thromboembolism
Prognosis
Pulmonary embolism
medicine.anatomical_structure
diaphragm
Host-Pathogen Interactions
Cardiology and Cardiovascular Medicine
Coronavirus Infections
Respiratory Insufficiency
medicine.medical_specialty
Pneumonia
Viral
Translational research
03 medical and health sciences
Betacoronavirus
medicine
Brief Reviews
Animals
Humans
Intensive care medicine
Pandemics
business.industry
SARS-CoV-2
COVID-19
acute respiratory distress syndrome
thromboembolism
medicine.disease
Respiration
Artificial
infection
respiratory system
030104 developmental biology
Clinical research
Airway
business
Pulmonary Embolism
Zdroj: Brosnahan, S B, Jonkman, A H, Kugler, M C, Munger, J S & Kaufman, D A 2020, ' COVID-19 and Respiratory System Disorders: Current Knowledge, Future Clinical and Translational Research Questions ', Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 40, no. 11, pp. 2586-2597 . https://doi.org/10.1161/ATVBAHA.120.314515
Arteriosclerosis, Thrombosis, and Vascular Biology
DOI: 10.1161/ATVBAHA.120.314515
Popis: The severe acute respiratory syndrome coronavirus-2 emerged as a serious human pathogen in late 2019, causing the disease coronavirus disease 2019 (COVID-19). The most common clinical presentation of severe COVID-19 is acute respiratory failure consistent with the acute respiratory distress syndrome. Airway, lung parenchymal, pulmonary vascular, and respiratory neuromuscular disorders all feature in COVID-19. This article reviews what is known about the effects of severe acute respiratory syndrome coronavirus-2 infection on different parts of the respiratory system, clues to understanding the underlying biology of respiratory disease, and highlights current and future translation and clinical research questions. Graphic Abstract: A graphic abstract is available for this article.
Databáze: OpenAIRE
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