Beta-adrenoceptor-stimulated renin release is blunted in old rats
| Autor: | W H Beierwaltes, K Engels, Christine Baylis |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Male
medicine.medical_specialty Aging Adrenergic Stimulation Biology Plasma renin activity Rats Sprague-Dawley Renin-Angiotensin System Reference Values Stress Physiological Internal medicine Renin–angiotensin system Receptors Adrenergic beta Renin medicine Animals Receptor General Medicine Beta adrenoceptor Propranolol Blockade Rats Disease Models Animal Endocrinology Mechanism of action Nephrology medicine.symptom |
| Zdroj: | Journal of the American Society of Nephrology : JASN. 9(7) |
| ISSN: | 1046-6673 |
| Popis: | Plasma renin activity (PRA) was similar in young versus old male Sprague Dawley rats under unstressed conditions (1.3 +/- 0.2 versus 1.8 +/- 0.3 ng angiotensin I/ml per min). Airjet stress increases PRA in young but not old rats (13.9 +/- 3.8 versus 2.9 +/- 0.8 ng angiotensin I/ml per min), respectively. This response is ablated in young rats by beta-adrenoceptor blockade, suggesting that the increased PRA is mediated by beta-adrenoceptors, and this response was blunted in old rats. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|