Peptide fragment 66-77 of monocyte chemoattractant protein 1 and its retro-enantio analogue inhibits the migration of cells in vitro and in vivo

Autor:	N. B. Kukhtina, V. N. Bushuev, A. S. Molokoedov, T. L. Krasnikova, Aref'eva Ti, A. A. Az’muko, M. G. Melekhov, Maria Sidorova, Zh. D. Bespalova
Předmět:	chemistry.chemical_classification Chemokine biology Chemistry Monocyte Organic Chemistry Inflammation Peptide Biochemistry Peripheral blood mononuclear cell In vitro chemistry.chemical_compound medicine.anatomical_structure In vivo medicine biology.protein Peptide synthesis medicine.symptom
Zdroj:	Scopus-Elsevier
Popis:	The retro-enantio-analogue of peptide 66–77 of the chemokine MCP-1 and two hexapeptide fragments 66–71 and 72–77 of the C-terminal sequence of this protein were synthesized using the Fmoc strategy of solid phase peptide synthesis. The effect of the synthetic peptides upon the MCP-1-stimulated migration of THP-1 mononuclear cells was studied in vitro. The activity of the retro-enantio analogue was found to be comparable with that of the initial peptide 66–77: both peptides inhibit the migration of monocytes and granulocytes into inflammation zones of experimental animals.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::295fcf88826c4f39bf3df7e78fae1712 http://www.scopus.com/inward/record.url?eid=2-s2.0-33744536561&partnerID=MN8TOARS Zobrazit plný text záznamu