Developmental genetics of color pattern establishment in cats
| Autor: | Gregory S. Barsh, Kelly A. McGowan, Christopher B. Kaelin |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Keratinocytes
Genotype Science Epidermal thickness General Physics and Astronomy Evolutionary biology Biology Development medicine.disease_cause General Biochemistry Genetics and Molecular Biology Article Wnt inhibitor Gene expression medicine Animals Author Correction Gene Wnt Signaling Pathway Skin Regulation of gene expression Mutation Multidisciplinary CATS Pigmentation Wnt signaling pathway Gene Expression Regulation Developmental RNA sequencing Cat General Chemistry Hair follicle Phenotype medicine.anatomical_structure Developmental genetics Animals Domestic Cats Pattern formation Intercellular Signaling Peptides and Proteins Pattern type Epidermis Single-Cell Analysis |
| Zdroj: | Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021) Nature Communications |
| ISSN: | 2041-1723 |
| Popis: | Intricate color patterns are a defining aspect of morphological diversity in the Felidae. We applied morphological and single-cell gene expression analysis to fetal skin of domestic cats to identify when, where, and how, during fetal development, felid color patterns are established. Early in development, we identify stripe-like alterations in epidermal thickness preceded by a gene expression pre-pattern. The secreted Wnt inhibitor encoded by Dickkopf 4 plays a central role in this process, and is mutated in cats with the Ticked pattern type. Our results bring molecular understanding to how the leopard got its spots, suggest that similar mechanisms underlie periodic color pattern and periodic hair follicle spacing, and identify targets for diverse pattern variation in other mammals. Intricate color patterns are a defining aspect of morphological diversity in the Felidae. Here the authors apply morphological and single-cell gene expression analysis to fetal skin of domestic cats to identify when, where, and how, during fetal development, felid color patterns are established. |
| Databáze: | OpenAIRE |
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