New cytotoxic sulfated saponins from the starfishCertonardoa semiregularis
| Autor: | Chong-Ok Lee, Song-Ja Bae, Weihong Wang, Hyo-Jin Jang, Jongki Hong, Sook Shin, Jee H. Jung |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Stereochemistry
Organic Chemistry Cell Starfish Antineoplastic Agents Brine shrimp Certonardoa semiregularis Saponins Biology biology.organism_classification medicine.anatomical_structure Sulfation Biochemistry Cell culture Drug Discovery Tumor Cells Cultured medicine Animals Humans Molecular Medicine Cytotoxic T cell Sulfonic Acids Cytotoxicity |
| Zdroj: | Archives of Pharmacal Research. 28:285-289 |
| ISSN: | 1976-3786 0253-6269 |
| Popis: | Two new sulfated saponins designated as certonardosides P2 and I3 (1 and 2) were isolated from the brine shrimp active fraction of the MeOH extract of the starfish Certonardoa semiregularis. The structures were determined on the basis of spectral analysis. Compounds 1 and 2 were tested for cytotoxicity against five human tumor cell lines (A549, SK-OV-3, SK-MEL-2, XF498, and HCT15), and compound 1 displayed significant cytotoxicity against the SK-MEL-2 skin cancer cell. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink