Cannabidiol disrupts conditioned fear expression and cannabidiolic acid reduces trauma-induced anxiety-related behaviour in mice
| Autor: | Jia Lin Luo, Jonathon C. Arnold, Cilla Zhou, Neda Assareh, Richard C. Kevin, Anand Gururajan |
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| Rok vydání: | 2020 |
| Předmět: |
Male
Fear memory medicine.drug_class Conditioning Classical Pharmacology Contextual fear Anxiety digestive system Anxiolytic 03 medical and health sciences Epilepsy Mice 0302 clinical medicine Memory medicine Animals Cannabidiol Fear conditioning business.industry Cannabinoids Fear medicine.disease digestive system diseases 030227 psychiatry Mice Inbred C57BL Psychiatry and Mental health surgical procedures operative Cannabidiolic acid Anti-Anxiety Agents Wounds and Injuries medicine.symptom business 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Behavioural pharmacology. 31(6) |
| ISSN: | 1473-5849 |
| Popis: | The major phytocannabinoid cannabidiol (CBD) has anxiolytic properties and lacks tetrahydrocannabinol-like psychoactivity. Cannabidiolic acid (CBDA) is the acidic precursor to CBD, and this compound appears more potent than CBD in animal models of emesis, pain and epilepsy. In this short report, we aimed to examine whether CBDA is more potent than CBD in disrupting expression of conditioned fear and generalised anxiety-related behaviour induced by Pavlovian fear conditioning. Mice underwent fear conditioning and 24 h later were administered CBD and CBDA before testing for fear expression and generalized anxiety-like behaviour. We found that CBD and CBDA had dissociable effects; while CBD but not CBDA disrupted cued fear memory expression, CBDA but not CBD normalized trauma-induced generalized anxiety-related behaviour. Neither phytocannabinoid affected contextual fear expression. Our findings form the basis for future experiments examining whether phytocannabinoids, alone and in combination, are effective in these mouse models of fear and anxiety. |
| Databáze: | OpenAIRE |
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