Human Congenital Infection With Trypanosoma cruzi Induces Phenotypic and Functional Modifications of Cord Blood NK Cells

Autor: Aurélie Berthe, Yves Carlier, Faustino Torrico, Veronique M. Braud, Carine Truyens, Emmanuel Hermann, Amilcar Flores, Cristina Alonso-Vega, Lorenzo Moretta, Marisol Cordova
Přispěvatelé: Institut de pharmacologie moléculaire et cellulaire (IPMC), Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)
Rok vydání: 2006
Předmět:
MESH: Interleukin-12
MESH: Membrane Glycoproteins
MESH: Interleukin-15
MESH: Down-Regulation
Granzymes
Interleukin 21
0302 clinical medicine
Cytotoxic T cell
MESH: Animals
MESH: Serine Endopeptidases
Receptors
Immunologic
Interleukin-15
0303 health sciences
Membrane Glycoproteins
Janus kinase 3
MESH: Infant
Newborn
Serine Endopeptidases
MESH: Antigens
CD56
Fetal Blood
Interleukin-12
CD56 Antigen
3. Good health
Killer Cells
Natural
Phenotype
NK Cell Lectin-Like Receptor Subfamily K
Cord blood
Interleukin 12
Receptors
Natural Killer Cell
MESH: Trypanosoma cruzi
MESH: Killer Cells
Natural
MESH: Interferon Type II
Trypanosoma cruzi
Down-Regulation
Biology
MESH: Phenotype
Interferon-gamma
03 medical and health sciences
Animals
Humans
MESH: Chagas Disease
MESH: Fetal Blood
[SDV.BBM]Life Sciences [q-bio]/Biochemistry
Molecular Biology
Chagas Disease
MESH: Receptors
Immunologic
030304 developmental biology
MESH: Granzymes
MESH: Humans
Natural Cytotoxicity Triggering Receptor 3
Lymphokine-activated killer cell
Natural Cytotoxicity Triggering Receptor 1
Infant
Newborn
MESH: Interleukin-2
NKG2D
Granzyme B
Pediatrics
Perinatology and Child Health
Immunology
Interleukin-2
030215 immunology
Zdroj: Pediatric Research
Pediatric Research, Nature Publishing Group, 2006, 60 (1), pp.38-43. ⟨10.1203/01.pdr.0000220335.05588.ea⟩
ISSN: 1530-0447
0031-3998
DOI: 10.1203/01.pdr.0000220335.05588.ea
Popis: We studied the phenotype and activity of cord blood natural killer (NK) cells in newborns congenitally infected with Trypanosoma cruzi. We found that the proportion of CD56(bright) NK cells was significantly decreased in cord blood from these newborns, suggesting they may have been recruited to secondary lymphoid organs. The remaining CD56(bright) NK cells exhibited a defective ability in the production of interferon (IFN)-gamma following in vitro activation with interleukin (IL)-12 + IL-2 or IL-12 + IL-15 cytokines, as compared with NK cells from uninfected newborns. In addition, cord blood NK cells from congenitally infected newborns stimulated with cytokines have a decreased release of granzyme B (GrB) when incubated with K562 target cells. This defect in cytotoxic effector function is associated with a reduced surface expression of activating NK receptors (NKp30, NKp46, and NKG2D) on CD56(dim) NK cells compared with uninfected newborns. These alterations of fetal NK cells from congenitally infected newborns may reflect a down-regulation of the NK cell response after an initial peak of activation and could also be the result of T. cruzi modulating the immune response.
Databáze: OpenAIRE
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