Subglottic Squamous Cell Carcinoma

Autor: Amit A. Patel, Tapan D. Patel, Soly Baredes, Richard Chan Woo Park, Jean Anderson Eloy, Emily Marchiano, Dhruv M. Patel, Yuhan E. Xue
Rok vydání: 2015
Předmět:
Zdroj: Otolaryngology–Head and Neck Surgery. 154:315-321
ISSN: 1097-6817
0194-5998
DOI: 10.1177/0194599815618190
Popis: Subglottic squamous cell carcinoma (SCCa) is a rare malignancy representing5% of all laryngeal cancers. Patients often present with late-stage disease, and survival outcomes are reportedly worse than those for SCCa in other regions of the larynx.Analysis of a population-based tumor registry.Academic medical center.The US National Cancer Institute's Surveillance, Epidemiology, and End Results database was queried for cases of subglottic SCCa from 1973 to 2011 (889 cases). Resulting data were analyzed, including patient demographics, therapeutic measures, and survival outcomes.Subglottic SCCa most frequently occurred in the fifth to seventh decade of life, with a mean age at diagnosis of 65.7 ± 11.3 years. There was a strong male predilection, with a male:female ratio of 3.83:1. Most patients were stage III and IV (64.4%) per the American Joint Committee on Cancer. The most common treatment modality was a combination of radiotherapy and surgery (38.8%), followed by radiotherapy alone (33.9%), and surgery alone (17.0%). Overall 5-year disease-specific survival rate was 53.7%. When stratified by treatment modality, 5-year disease-specific survival was 62.4% for surgery alone, 56.7% for radiotherapy alone, and 55.1% for surgery with adjuvant radiotherapy (P = .3892).This study represents the largest cohort of subglottic SCCa. It shows a strong predilection for men in the US population. Surgery with adjuvant radiotherapy was the most commonly employed treatment modality. No statistically significant differences were observed in 5-year DSS by treatment modality.
Databáze: OpenAIRE
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