Oseltamivir induces favorable response on oxidative damage in the brain of rats treated with Bezafibrate
| Autor: | Quetzalli Veloz Corona, Lulú Sánchez Reyes, Norma Osnaya Brizuela, Gerardo Barragán Mejía, Maribel Ortiz Herrera, Armando Valenzuela Peraza, David Calderón Guzmán, Hugo Juárez Olguín |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Male
0301 basic medicine Oseltamivir Dopamine Oxidative phosphorylation Pharmacology Serotonergic Oxidative damage 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine medicine Animals Rats Wistar Adenosine Triphosphatases Bezafibrate business.industry General Neuroscience Dopaminergic Brain Hydrogen Peroxide General Medicine Hydroxyindoleacetic Acid Glutathione Rats Oxidative Stress 030104 developmental biology chemistry Hypotriglyceridemia Lipid Peroxidation business 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | International Journal of Neuroscience. 132:574-581 |
| ISSN: | 1543-5245 0020-7454 |
| DOI: | 10.1080/00207454.2020.1828882 |
| Popis: | The purpose was to measure the effect of Oseltamivir on oxidative biomarkers and dopaminergic and serotonergic systems in brain of rats with induced hypotriglyceridemia by Bezafibrate.Male young Wistar rats were treated as follows: group 1, NaCl 0.9%, (Controls); group 2, Oseltamivir (100 mg/kg); group 3, single dose of Bezafibrate (150 mg/kg); group 4, four dose of Bezafibrate; group 5, single dose of Bezafibrate + Oseltamivir and group 6, four doses of Bezafibrate + Oseltamivir. Drugs were given orally. Triglycerides, Dopamine, 5-hydroxyindoleacetic acid (5-HIAA), Glutathione (GSH), Hydrogen peroxide (HOseltamivir treated animals showed lower GSH and lipid peroxidation levels and an increment in 5-HIAA in the three evaluated brain regions. Treatment with Oseltamivir also reduces H |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|