Histopathological lesions following intramuscular administration of saline in laboratory rodents and rabbits
| Autor: | Paul Howroyd, Céline Thuilliez, Sarah Gould, Laetitia Dorso, Franck Chanut, Roger Burnett |
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| Rok vydání: | 2009 |
| Předmět: |
Male
Pathology medicine.medical_specialty medicine.medical_treatment Inflammation Sodium Chloride Toxicology Injections Intramuscular Peripheral blood mononuclear cell Pathology and Forensic Medicine Toxicology studies Mice Fibrosis medicine Animals Rats Wistar Muscle Skeletal Saline business.industry Cell Biology General Medicine medicine.disease Rats Female Rabbits medicine.symptom Intramuscular injection business Infiltration (medical) |
| Zdroj: | Experimental and Toxicologic Pathology. 61:13-21 |
| ISSN: | 0940-2993 |
| DOI: | 10.1016/j.etp.2008.07.003 |
| Popis: | This review was undertaken to assess the nature and incidence of procedure-related changes in mice, rats and rabbits which received saline solution by intramuscular injection. Data were collected on the injection sites from 7 studies representing 152 animals. The original observations by the different study pathologists from both control and treated animals were evaluated in order to create a glossary of preferred terms to be used in toxicology studies. These standardized terms were then applied to changes observed in the saline-treated animals. The review showed that the most severe of the procedure-related lesions were only of a slight level. Two days post-injection, the local reactions were mainly composed of minimal infiltration by mononuclear cells (lymphocytes and macrophages) with occasional degeneration of myofibres. From 10 to 42 days post-injection, lesions showed regeneration of myofibres and some fibrosis. In rats, the number of injections at each site influenced inflammatory infiltrate and degenerative lesions. |
| Databáze: | OpenAIRE |
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