The role of cAMP in flagellation of Salmonella typhimurium
| Autor: | Tetsuo Iino, Yoshibumi Komeda, Jun-Ichi Ishidsu, Hideho Suzuki |
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| Rok vydání: | 1975 |
| Předmět: |
Salmonella typhimurium
Messenger RNA Mutation biology Effector Mutant Adenylate kinase medicine.disease_cause Molecular biology Phenotype Bacterial Proteins Cistron cAMP receptor protein Flagella Genes Regulator Cyclic AMP Genetics biology.protein medicine RNA Messenger Molecular Biology Flagellin Adenylyl Cyclases |
| Zdroj: | Molecular and General Genetics MGG. 142:289-298 |
| ISSN: | 1432-1874 0026-8925 |
| DOI: | 10.1007/bf00271253 |
| Popis: | A mutational alteration either in adenylate cyclase (cya-) or in cyclic-3'5'-AMP (cAMP) receptor protein (crp-) rendered Salmonella typhimurium incapable of producing flagella. The amount of mRNA specific for flagellin in these mutants was almost negligible when assayed in an in vitro protein synthesizing system. A secondary mutation cfs, partially suppressing the cya- mutation, was identified among the revertants of cya-. A mutation in the same cistron as cfs resulted in a non-flagellate phenotype either by itself or in combination with cfs. The cistron, which was given the gene symbol flaT, was located between flaE and flaL. It was suggested that cAMP receptor protein together with cAMP modulates the gene flaT, which in turn acts as a positive effector on the synthesis of active mRNA specific for flagellin. |
| Databáze: | OpenAIRE |
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