Contrast-Enhanced Digital Mammography Screening for Intermediate-Risk Women With a History of Lobular Neoplasia
| Autor: | Janice S. Sung, Molly P Hogan, Maxine S. Jochelson, Elizabeth A. Morris, Tali Amir, Varadan Sevilimedu |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Risk Breast biopsy medicine.medical_specialty Digital mammography Breast imaging Contrast Media Breast Neoplasms Sensitivity and Specificity Likelihood ratios in diagnostic testing Article 030218 nuclear medicine & medical imaging 03 medical and health sciences Breast cancer screening 0302 clinical medicine Breast cancer Humans Medicine Radiology Nuclear Medicine and imaging Breast Aged Retrospective Studies medicine.diagnostic_test business.industry General Medicine Middle Aged CEDM medicine.disease Radiographic Image Enhancement Carcinoma Lobular 030220 oncology & carcinogenesis Female Radiology business Mammography Lobular Neoplasia |
| Zdroj: | AJR Am J Roentgenol |
| ISSN: | 1546-3141 0361-803X |
| Popis: | OBJECTIVE. The objective of this study was to assess to the role of contrast-enhanced digital mammography (CEDM) as a screening tool in women at intermediate risk for developing breast cancer due to a personal history of lobular neoplasia without additional risk factors. MATERIALS AND METHODS. In this institutional review board-approved, observational, retrospective study, we reviewed our radiology department database to identify patients with a personal history of breast biopsy yielding lobular neoplasia who underwent screening CEDM at our institution between December 2012 and February 2019. A total of 132 women who underwent 306 CEDM examinations were included. All CEDM examinations were interpreted by dedicated breast imaging radiologists in conjunction with a review of the patient’s clinical history and available prior breast imaging. In statistical analysis, sensitivity, specificity, NPV, positive likelihood ratio, and accuracy of CEDM in detecting cancer were determined, with pathology or 12-month imaging follow-up serving as the reference standard. RESULTS. CEDM detected cancer in six patients and showed an overall sensitivity of 100%, specificity of 88% (95% CI, 84–92%), NPV of 100%, and accuracy of 88% (95% CI, 84–92%). The positive likelihood ratio of 8.33 suggested that CEDM findings are 8.3 times more likely to be positive in an individual with breast cancer when compared with an individual without the disease. CONCLUSION. CEDM shows promise as a breast cancer screening examination in patients with a personal history of lobular neoplasia. Continued investigation with a larger patient population is needed to determine the true sensitivity and positive predictive value of CEDM for these patients. |
| Databáze: | OpenAIRE |
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