Isolation of a dihydrobenzofuran lignan, icariside E4, with an antinociceptive effect from Tabebuia roseo-alba (Ridley) Sandwith (Bignoniaceae) bark
| Autor: | Emiliano Barreto, Jesu C. Ferreira-Júnior, Lucia M. Conserva, Araken Cavalcante-Neto, Rosangela P. Lyra Lemos, Genilda C. de Omena-Neta |
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| Rok vydání: | 2014 |
| Předmět: |
Male
Hot Temperature Pain Bignoniaceae Pharmacology Tabebuia Lignans Glibenclamide Mice chemistry.chemical_compound KATP Channels Formaldehyde Drug Discovery medicine Animals Glycosides Acetic Acid Pain Measurement Lignan Analgesics Behavior Animal Dose-Response Relationship Drug biology Plant Extracts Chemistry Organic Chemistry biology.organism_classification Yohimbine Nociception visual_art Plant Bark visual_art.visual_art_medium Molecular Medicine Bark Licking Injections Intraperitoneal medicine.drug |
| Zdroj: | Archives of Pharmacal Research. 38:950-956 |
| ISSN: | 1976-3786 0253-6269 |
| DOI: | 10.1007/s12272-014-0468-4 |
| Popis: | The antinociceptive activity of icariside E4, a dihydrobenzofuran-type lignan isolated from Tabebuia roseo-alba (Ridley) Sandwith (Bignoniaceae) bark, was evaluated in mice by using chemical and thermal models of nociception. Intraperitoneal (i.p.) administration of crude T. roseo-alba bark extract and its methanol fraction inhibited acetic acid-induced abdominal constriction in mice. Furthermore, i.p. administration of 0.1, 1, and 10 mg/kg of icariside E4 reduced the number of writhes evoked by acetic acid injection by 46.9, 82.3, and 66.6%, respectively. Icariside E4 administration had no effect in the first phase of the formalin test, but it reduced nociceptive behavior in the second phase as indicated by a reduction in the licking time. Icariside E4 did not modify thermal nociception in the hot-plate test model, suggesting that it had a peripheral antinociceptive action. The antinociceptive effect of icariside E4 in the writhing test was reversed by pre-administration of glibenclamide, but not of naloxone, atropine, yohimbine, or haloperidol. Together, these results indicated that the antinociceptive activity of icariside E4 from T. roseo-alba in models of chemical pain occurred through ATP-sensitive K(+) channel-dependent mechanisms. |
| Databáze: | OpenAIRE |
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