Flavonoids of the Heartwood of Cotinus coggygria Scop. Showing Protective Effect on Human Lymphocyte DNA
| Autor: | Slobodan Milosavljevic, Iris Djordjevic, Boris Mandic, Vele Tesevic, Miroslava Stankovic, Nina Todorovic, Miroslav Novakovic |
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| Rok vydání: | 2021 |
| Předmět: |
Pharmacology
0303 health sciences DNA protective activity Plant Science General Medicine cytokinesis-block micronucleus assay 3. Good health Cotinus coggygria Scop 03 medical and health sciences 0302 clinical medicine Complementary and alternative medicine 030220 oncology & carcinogenesis Drug Discovery flavonoids Cotinus coggygriaScop 030304 developmental biology |
| Zdroj: | Natural Product Communications |
| Popis: | In continuation of our study on Cotinus coggygria from Serbia, 10 known flavonoids (1-10) were isolated from the methylene chloride/methanol extract of the heartwood. They were tested for in vitro protective effect against chromosome aberrations in peripheral human lymphocytes, using the cytokinesis-block micronucleus assay. All tested compounds (in minimal doses of 1 μg/mL) exerted a beneficial effect by decreasing DNA damage of human lymphocytes in the range of 24.2% to 54.5%, better than the radio protectant control, amifostine. Functional groups, such as 3′,4′-dihydroxyphenyl (catechol), 5-OH, 3-OH, and 4-keto in flavonoids (3-keto in aurones), which play a key role in antioxidant activity, are proposed to be responsible for the DNA protective activity of the tested compounds. |
| Databáze: | OpenAIRE |
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