Effect of Omega-3 fatty acids on blood pressure and serum lipids in continuous ambulatory peritoneal dialysis patients
| Autor: | Sayed Mohsen Hosseini, Mojgan Mortazavi, Nooshin Keyvandarian, Afsoon Emami Naini, Shahram Taheri |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
Blood lipids lcsh:RS1-441 continuous ambulatory peritoneal dialysis Pharmacy Placebo Placebo group Gastroenterology lcsh:Pharmacy and materia medica Internal medicine Hyperlipidemia medicine Pharmacology (medical) General Pharmacology Toxicology and Pharmaceutics Omega-3 medicine.diagnostic_test business.industry Continuous ambulatory peritoneal dialysis medicine.disease Blood pressure serum lipids Surgery Clinical trial Original Article business Lipid profile |
| Zdroj: | Journal of Research in Pharmacy Practice, Vol 4, Iss 3, Pp 135-141 (2015) Journal of Research in Pharmacy Practice |
| ISSN: | 2319-9644 |
| Popis: | Objective: Hypertension and hyperlipidemia are two major risk factors for cardiovascular disease in continuous ambulatory peritoneal dialysis (CAPD) patients. This study was designed to investigate the effect of omega-3 fatty acids on blood pressure (BP) and serum lipids in CAPD patients. Methods: This study was a randomized double-blind clinical trial in which 90 CAPD patients were randomly assigned to either the omega-3 or the placebo group. Patients in omega-3 group received 3 g/day omega-3 for 8 weeks, whereas patients in the control group received placebo. At baseline and at the end of 8 weeks, the patients’ BP was controlled, and serum biochemistry was measured. Findings: Mean systolic BP decreased (–22.2 ± 14.2 mmHg) in the omega-3 group at the end of the study while in the placebo group increased (+0.5 ± 30.2 mmHg) (P < 0.0001). Mean diastolic BP of the omega-3 group decreased more (–11.95 ± 11.9 mmHg) comparing with the placebo group (–1.1 ± 17.3 mmHg) (P = 0.001). There were no significant differences between the two groups in mean changes in serum triglyceride, and total, high-density lipoprotein, and low-density lipoprotein cholesterol. Conclusion: The results of this study indicate that omega-3 reduced BP significantly but had no effect on lipid profile in our CAPD patients. |
| Databáze: | OpenAIRE |
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