COGENT (COlorectal cancer GENeTics) revisited
| Autor: | Richard Houlston, Federico Bolado, Paolo Peterlongo, Angel Carracedo, Oliver Sieber, Virginia Piñol, Jochen Hampe, Andrew Green, Anneke Lucassen, Albert Tenesa, JOAQUIN CUBIELLA, Gareth Evans, Antoni Castells, Eloy Sánchez Hernández, Koichi Matsuda, Pavel Vodička, Markus M. Lerch, Tom Van Wezel, Lauri Aaltonen, Tim Bishop, Rodney Scott, Robert Hofstra |
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| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Oncology
medicine.medical_specialty Colorectal cancer Health Toxicology and Mutagenesis Genome-wide association study Biology Gene mutation Toxicology 03 medical and health sciences 0302 clinical medicine Breast cancer Internal medicine Genetics medicine Humans Genetic Predisposition to Disease Allele Genetics (clinical) 030304 developmental biology 0303 health sciences Polymorphism Genetic Microsatellite instability Polymorphism Genetic - genetics Original Articles medicine.disease 3. Good health Colorectal Neoplasms - diagnosis - genetics 030220 oncology & carcinogenesis DNA mismatch repair Colorectal Neoplasms Colorectal cancer genetics Genes Neoplasm |
| Zdroj: | Mutagenesis, 27(2), 143-151 Mutagenesis |
| Popis: | Many colorectal cancers (CRCs) develop in genetically susceptible individuals most of whom are not carriers of germ line mismatch repair or APC gene mutations and much of the heritable risk of CRC appears to be attributable to the co-inheritance of multiple low-risk variants. The accumulated experience to date in identifying this class of susceptibility allele has highlighted the need to conduct statistically and methodologically rigorous studies and the need for the multi-centre collaboration. This has been the motivation for establishing the COGENT (COlorectal cancer GENeTics) consortium which now includes over 20 research groups in Europe, Australia, the Americas, China and Japan actively working on CRC genetics. Here, we review the rationale for identifying low-penetrance variants for CRC and the current and future challenges for COGENT. |
| Databáze: | OpenAIRE |
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