Diagnostic implications of p16 expression in serous papillary endometrial cancer
| Autor: | Ludmila Litwin, Amnon Amit, Lior Lowenstein, Hedwiga Kerner, Itamar Netzer |
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| Rok vydání: | 2011 |
| Předmět: |
Oncology
medicine.medical_specialty Pathology Prognostic factor endocrine system diseases Internal medicine Carcinoma Biomarkers Tumor Medicine Humans Cyclin-Dependent Kinase Inhibitor p16 Aged business.industry Endometrial cancer Obstetrics and Gynecology P16 protein Middle Aged medicine.disease female genital diseases and pregnancy complications Endometrial Neoplasms Neoplasm Proteins Serous fluid Cystadenocarcinoma Papillary Immunohistochemistry Female business |
| Zdroj: | International journal of gynecological cancer : official journal of the International Gynecological Cancer Society. 21(8) |
| ISSN: | 1525-1438 |
| Popis: | Objective: The purpose of this study was to examine whether the degree of expression of the p16 protein in serous papillary endometrial cancer bears a prognostic significance. The secondary objective was to establish the value of p16 immunohistochemical staining as an adjunct to diagnosis. Study Design: Archived paraffin blocks holding specimens from the uteri of 31 serous papillary and 31 endometrioid endometrial carcinoma patients were recut and restained for p16 and p53. Results: Overexpression of p16 was found in 78% of the serous papillary patients versus 36% of the endometrioid patients. p16 was not found to be an independent prognostic factor in serous papillary endometrial carcinoma. Conclusions: Although p16 was not found to have prognostic significance in serous papillary endometrial carcinoma, it may be valuable as a diagnostic adjunct in histologically ambiguous tumors. |
| Databáze: | OpenAIRE |
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