Failure of Short-Term Nutritional Convalescence to Reverse the Adverse Hemodynamic Effects of Protein-Calorie Malnutrition in Dogs
| Autor: | Ronald M. Abel, Jeffery Paul |
|---|---|
| Rok vydání: | 1979 |
| Předmět: |
medicine.medical_specialty
Time Factors 030309 nutrition & dietetics Heart Ventricles media_common.quotation_subject Medicine (miscellaneous) Hemodynamics Protein-Energy Malnutrition Beagle law.invention 03 medical and health sciences chemistry.chemical_compound Dogs 0302 clinical medicine law Weight loss Internal medicine Cardiopulmonary bypass Animals Medicine Nutritional Physiological Phenomena Adverse effect Isovolumetric contraction media_common 0303 health sciences Nutrition and Dietetics Glycogen business.industry Myocardium Convalescence Heart Myocardial Contraction Surgery chemistry Cardiology 030211 gastroenterology & hepatology medicine.symptom business |
| Zdroj: | Journal of Parenteral and Enteral Nutrition. 3:211-214 |
| ISSN: | 1941-2444 0148-6071 |
| DOI: | 10.1177/014860717900300401 |
| Popis: | We previously reported that protein-calorie malnutrition (PCM) exerts adverse hemodynamic effects on left ventricular (LV) structure and function. In the present experiments, we tried to determine the duration of these adverse effects by inducing significant weight loss in matched beagle dogs followed by a short-term course of nutritional repletion. Following restitution of initial body weight, the animals were placed on total cardiopulmonary bypass and an isovolumetric LV preparation was established to determine baseline LV function compared with matched animals that remained normally-nourished, and with a third group in which the effects of PCM were not reversed. Decreases in LV compliance persisted following refeeding as did the decreases in the first derivative of LV pressure (LV dp/dt). Although animals re-fed ordinary diets following acute weight loss restored normal concentrations of myocardial glycogen, cardiac abnormalities persited for more than one month following refeeding. These results suggest that the adverse effects of semistarvation on LV functions cannot be completely reversed by short-term refeeding. |
| Databáze: | OpenAIRE |
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