Perspectives in melanoma: Meeting report from the Melanoma Bridge (30 November–2 December, 2017, Naples, Italy)
Autor: | Corrado Caracò, Claus Garbe, Gennaro Ciliberto, Sanjiv S. Agarwala, Janice M. Mehnert, Nicola Mozzillo, Francesco M. Marincola, Paolo A. Ascierto, Thomas F. Gajewski, Soldano Ferrone, Giuseppe Masucci, Ena Wang, Reinhard Dummer, Magdalena Thurin, Gerardo Botti, Michael A. Postow, Giuseppe Palmieri, Jason J. Luke, Michael A. Davies, Igor Puzanov, Carlo Bifulco, Stephen P. Schoenberger |
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Přispěvatelé: | University of Zurich, Ascierto, Paolo A |
Rok vydání: | 2018 |
Předmět: |
0301 basic medicine
Oncology medicine.medical_specialty Electrochemotherapy medicine.medical_treatment lcsh:Medicine 610 Medicine & health Genetics and Molecular Biology Ipilimumab Meeting Report Target therapy General Biochemistry Genetics and Molecular Biology Targeted therapy 03 medical and health sciences 0302 clinical medicine 1300 General Biochemistry Genetics and Molecular Biology Internal medicine medicine Effective treatment Vemurafenib Melanoma Combination strategies Advanced melanoma business.industry lcsh:R 10177 Dermatology Clinic General Medicine Immunotherapy medicine.disease 3. Good health 030104 developmental biology 030220 oncology & carcinogenesis General Biochemistry business Biomarkers medicine.drug |
Zdroj: | Journal of translational medicine (Online) 16 (2018). doi:10.1186/s12967-018-1568-6 info:cnr-pdr/source/autori:Ascierto, Paolo A.; Puzanov, Igor; Agarwala, Sanjiv S.; Bifulco, Carlo; Botti, Gerardo; Caraco, Corrado; Ciliberto, Gennaro; Davies, Michael A.; Dummer, Reinhard; Ferrone, Soldano; Gajewski, Thomas F.; Garbe, Claus; Luke, Jason J.; Marincola, Francesco M.; Masucci, Giuseppe; Mehnert, Janice M.; Mozzillo, Nicola; Palmieri, Giuseppe; Postow, Michael A.; Schoenberger, Stephen P.; Wang, Ena; Thurin, Magdalena/titolo:Perspectives in melanoma: Meeting report from the Melanoma Bridge (30 November-2 December, 2017, Naples, Italy)/doi:10.1186%2Fs12967-018-1568-6/rivista:Journal of translational medicine (Online)/anno:2018/pagina_da:/pagina_a:/intervallo_pagine:/volume:16 Journal of Translational Medicine, Vol 16, Iss 1, Pp 1-13 (2018) Journal of Translational Medicine |
ISSN: | 1479-5876 |
Popis: | Metastatic melanoma represents a challenging clinical situation and, until relatively recently, there was an absence of effective treatment options. However, in 2011, the advanced melanoma treatment landscape was revolutionised with the approval of the anti-cytotoxic T-lymphocyte-associated protein-4 checkpoint inhibitor ipilimumab and the selective BRAF kinase inhibitor vemurafenib, both of which significantly improved overall survival. Since then, availability of new immunotherapies, especially the anti-programmed death-1 checkpoint inhibitors, as well as other targeted therapies, have further improved outcomes for patients with advanced melanoma. Seven years on from the first approval of these novel therapies, evidence for the use of various immune-based and targeted approaches is continuing to increase at a rapid rate. Improved understanding of the tumour microenvironment and tumour immuno-evasion strategies has resulted in different approaches to target and harness the immune response. These new immune-based approaches offer the opportunity for various approaches with distinct modes of action being used in combination with one another, as well as combined with other treatment modalities such as targeted therapy, electrochemotherapy and surgery. The increasing number of treatment options that are now available has resulted in a growing need to identify which patients will derive most benefit from which treatments. Much research is now focused on the identification of biomarkers that can be utilised to help select patients for treatment. These and other recent advances in the management of melanoma were the focus of discussions at the third Melanoma Bridge meeting (30 November–2 December, 2017, Naples, Italy), which is summarised in this report. |
Databáze: | OpenAIRE |
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