Normal homeostasis of fibrinolysis in nephrogenic diabetes insipidus in spite of defective V2- receptor-mediated responses of tissue plasminogen activator release
| Autor: | H. S. Brink, F. H. M. Derkx, J. Stibbe, E. J. P. Brommer, M. A. D. H. Schalekamp |
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| Rok vydání: | 2008 |
| Předmět: |
Adult
Male Receptors Vasopressin medicine.medical_specialty Vasopressin medicine.medical_treatment Clinical Biochemistry Biochemistry Tissue plasminogen activator Internal medicine Arginine vasopressin receptor 2 Fibrinolysis medicine Homeostasis Humans Deamino Arginine Vasopressin Exertion Vasopressin receptor Receptors Angiotensin business.industry General Medicine Nephrogenic diabetes insipidus medicine.disease Plasminogen Inactivators Endocrinology Tissue Plasminogen Activator Kidney Diseases business Diabetes Insipidus medicine.drug |
| Zdroj: | European Journal of Clinical Investigation. 20:72-78 |
| ISSN: | 0014-2972 |
| DOI: | 10.1111/j.1365-2362.1990.tb01794.x |
| Popis: | Three patients with congenital, nephrogenic diabetes insipidus (NDI) from two unrelated families were tested for haemostatic and fibrinolytic responses to DDAVP infusion and venous occlusion. None of the three patients showed a response of factor VIII:C, vWF:Ag or t-PA to DDAVP, a V2-agonist. However, the baseline levels of these factors in the patients' plasma were normal and during venous occlusion a rise in t-PA antigen and t-PA activity was observed in all patients. One patient showed a definite response of the t-PA antigen level to exercise. It is concluded that (extrarenal) V2-receptor-mediated responses are absent in these patients, but that baseline homeostasis and the response to venous occlusion and physical exertion are intact. Presumably, these depend on other mechanisms. This observation denies a central role for vasopressin receptors in the on-demand regulation of clotting and clot dissolving properties of the blood. |
| Databáze: | OpenAIRE |
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