T-cell responses and previous exposure to hepatitis C virus in indeterminate blood donors
| Autor: | Eleanor Barnes, Nasser Semmo, Gillian Harcourt, Neil Smith, Craig J. Taylor, John Kurtz, Paul Klenerman |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Adult
Male T-Lymphocytes Hepacivirus T cell Hepatitis C virus viruses Immunoblotting Blood Donors medicine.disease_cause Virus Antigen-Antibody Reactions Immunoenzyme Techniques Flaviviridae Immune system Humans Medicine Aged biology business.industry Viral Core Proteins General Medicine Hepatitis C Antibodies Middle Aged biology.organism_classification Hepatitis C Virology medicine.anatomical_structure Immunology RNA Viral Female Viral disease Hepatitis C Antigens business Indeterminate |
| DOI: | 10.1016/s0140-6736(05)17787-3 |
| Popis: | Blood donors are routinely screened for hepatitis C virus infection. Some individuals have weak or restricted virus-specific antibody responses, and are classed as indeterminate. Such donors are almost always negative for viral RNA in blood. We postulated that previous transient virus exposure might account for some of these cases. With sensitive ex-vivo analyses of T-cell responses, we identified virus-specific responses in 15 of 30 indeterminate blood donors tested, compared with none in controls (p=0.0013). Additionally, these responses were typically focused on core-derived peptides. These findings suggest previous exposure to the virus in many indeterminate blood donors. |
| Databáze: | OpenAIRE |
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