Secretory carcinoma of salivary glands at the National Cancer Institute: A 20-year retrospective clinical, pathological, immunohistochemical and molecular study
| Autor: | Andreia Cristina de Melo, Luiz H. Araujo, Daniel Cohen Goldemberg, Priscila Valverde Fernandes, Lísia Daltro Borges Alves, Isabella dos Santos Guimarães, Elizangela Marques Rodrigues, Héliton Spíndola Antunes, Leandro de Souza Thiago, Ana Lúcia Amaral Eisenberg, Fernando Luiz Dias |
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| Rok vydání: | 2021 |
| Předmět: |
Cancer Research
medicine.medical_specialty Pathology Acinic cell carcinoma 03 medical and health sciences 0302 clinical medicine Mammaglobin Epidemiology Biomarkers Tumor medicine Humans 030223 otorhinolaryngology Pathological Retrospective Studies biology Carcinoma Acinar Cell business.industry Medical record Cancer Salivary Gland Neoplasms medicine.disease National Cancer Institute (U.S.) United States Cross-Sectional Studies Oncology 030220 oncology & carcinogenesis biology.protein Immunohistochemistry Oral Surgery Differential diagnosis business |
| Zdroj: | Oral Oncology. 117:105198 |
| ISSN: | 1368-8375 |
| DOI: | 10.1016/j.oraloncology.2021.105198 |
| Popis: | Objectives This study aim was to review cases of acinic cell carcinoma (the main differential diagnosis of secretory carcinoma) that were diagnosed and treated at the National Cancer Institute of Brazil (INCA) between 1996 and 2016. The primary objective was to identify underdiagnosed cases of secretory carcinoma via a clinical, immunopathological and molecular reassessment. Materials and methods This is a cross sectional study, with retrospective data collection from medical records and histological specimen review, with staining for periodic acid-Schiff (PAS) and PAS with diastase, immunohistochemistry for S-100, mammaglobin, and DOG-1, and droplet digital RT-PCR for ETV6-NTRK3. The Research Ethics Committee approved this study, and the patients allowed their participation through informed consent. Results Eighty-three cases of acinic cell carcinoma were diagnosed and treated in the specified period at INCA, of which, seven had their diagnosis changed to secretory carcinoma. Conclusion The present study adds seven cases of secretory carcinoma to the literature, contributing to a better understanding of the epidemiological, histological, immunohistochemical and molecular characteristics of this recently described tumor. Also, the use of a comprehensive diagnostic approach, including immunohistochemical and molecular methods, along with classical morphological studies, allowed the reclassification of acinic cell carcinoma to secretory carcinoma. |
| Databáze: | OpenAIRE |
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