Annexin Animal Models—From Fundamental Principles to Translational Research
| Autor: | Grewal, Thomas, Rentero, Carles, Enrich, Carlos, Wahba, Mohamed, Raabe, Carsten A., Rescher, Ursula |
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| Přispěvatelé: | Universitäts- und Landesbibliothek Münster |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
extracellular annexin functions
610 Medicine and health Anti-Inflammatory Agents Review annexins Translational Research Biomedical lcsh:Chemistry Mice Neoplasms Diabetes Mellitus Animals Homeostasis Nanotechnology human disease models ddc:610 Annexin A5 KO mice lcsh:QH301-705.5 Annexin A2 Annexin A1 Mice Knockout calcium Neovascularization Pathologic membrane trafficking membrane organization Cell Membrane Lipids Protein Transport Phenotype lcsh:Biology (General) lcsh:QD1-999 Medicine and health Disease Progression Peptides Protein Binding |
| Zdroj: | International Journal of Molecular Sciences, Vol 22, Iss 3439, p 3439 (2021) International Journal of Molecular Sciences |
| ISSN: | 1661-6596 1422-0067 |
| Popis: | Routine manipulation of the mouse genome has become a landmark in biomedical research. Traits that are only associated with advanced developmental stages can now be investigated within a living organism, and the in vivo analysis of corresponding phenotypes and functions advances the translation into the clinical setting. The annexins, a family of closely related calcium (Ca2+)- and lipid-binding proteins, are found at various intra- and extracellular locations, and interact with a broad range of membrane lipids and proteins. Their impacts on cellular functions has been extensively assessed in vitro, yet annexin-deficient mouse models generally develop normally and do not display obvious phenotypes. Only in recent years, studies examining genetically modified annexin mouse models which were exposed to stress conditions mimicking human disease often revealed striking phenotypes. This review is the first comprehensive overview of annexin-related research using animal models and their exciting future use for relevant issues in biology and experimental medicine. Finanziert durch den Open-Access-Publikationsfonds der Westfälischen Wilhelms-Universität Münster (WWU Münster). |
| Databáze: | OpenAIRE |
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