Limited Transmission Potential of Takeda’s Tetravalent Dengue Vaccine Candidate by Aedes albopictus
| Autor: | Janae L. Stovall, Claire Y.-H. Huang, Yee Tsuey Ong, Elizabeth A. Dietrich, Hansi Dean |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Aedes albopictus viruses 030231 tropical medicine Dengue Vaccines Aedes aegypti Dengue virus Serogroup Vaccines Attenuated medicine.disease_cause Virus Dengue fever Dengue 03 medical and health sciences 0302 clinical medicine Aedes Virology Chlorocebus aethiops medicine Animals Vero Cells Dengue vaccine biology virus diseases Articles Dengue Virus medicine.disease biology.organism_classification Insect Vectors Logistic Models 030104 developmental biology Infectious Diseases Vector (epidemiology) Female Parasitology |
| Zdroj: | The American Journal of Tropical Medicine and Hygiene. 97:1423-1427 |
| ISSN: | 1476-1645 0002-9637 |
| DOI: | 10.4269/ajtmh.17-0185 |
| Popis: | Recombinant live-attenuated chimeric tetravalent dengue vaccine viruses, TDV-1, -2, -3, and -4, contain the premembrane and envelope genes of dengue virus serotypes 1–4 in the replicative background of the attenuated dengue virus type-2 (DENV-2) PDK-53 vaccine strain. Previous results have shown that these recombinant vaccine viruses demonstrate limited infection and dissemination in Aedes aegypti and are unlikely to be transmitted by the primary mosquito vector of DENVs. In this report, we expand this analysis by assessing vector competence of all four serotypes of the TDV virus in Aedes albopictus, the secondary mosquito vector of DENVs. Our results indicate that these vaccine viruses demonstrate incompetence or defective infection and dissemination in these mosquitoes and will likely not be transmissible. |
| Databáze: | OpenAIRE |
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