Serum Nesfatin-1 Levels in Girls with Idiopathic Central Precocious Puberty
| Autor: | Oya Sayin, Ayça Altıncık |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
medicine.drug_class Endocrinology Diabetes and Metabolism Central nervous system Puberty Precocious Neuropeptide nesfatin-1 Nerve Tissue Proteins Body weight precocious puberty Body Mass Index Human puberty Endocrinology Internal medicine medicine Humans Nucleobindins Child Idiopathic central precocious puberty business.industry Body Weight Calcium-Binding Proteins Leuprolide acetate Fertility Agents Female Anthropometry DNA-Binding Proteins medicine.anatomical_structure Pediatrics Perinatology and Child Health nucleobindin-2 Original Article Female Leuprolide Gonadotropin business Body mass index |
| Zdroj: | Journal of Clinical Research in Pediatric Endocrinology |
| Popis: | Objective Nesfatin-1, an anorexigenic neuropeptide, is expressed mainly in the central nervous system and in some peripheral tissues. The role of nesfatin-1 in energy balance has been investigated. Despite the suggestion of a role for nesfatin-1 in reproductive function, data are limited on the role of nesfatin-1 in human puberty. Methods The aim of this study was to investigate the following: i) the role of nesfatin-1 in puberty, and ii) relationship between nesfatin-1 and anthropometric measurements and gonadotropin levels in girls with idiopathic central precocious puberty (CPP). Twenty-four girls with CPP (7.68±1.02 years) and 20 female, prepubertal, healthy controls (7.48±0.88 years) were enrolled in the study. All patients with CPP were treated by the intramuscular administration of leuprolide acetate at a daily dose of 3.75 mg for 28 days. Nesfatin-1 was measured before and during treatment. Results There was no difference in serum nesfatin-1 levels in girls with CPP and healthy controls [5.67 (2.5-20.6) mmol/L and 5.75 (2.51-9.64) mmol/L], respectively. There was a negative correlation between nesfatin-1 levels and body weight and body mass index-standard deviation score (p=0.01, r=-0.83; p=0.025, r=-0.81, respectively). No correlation was found between nesfatin-1 and gonadotropin, estradiol levels, uterine length or endometrial thickness. Conclusion The results of this study suggest that there are no differences between girls with CPP and healthy, prepubertal girls regarding nesfatin-1 levels. |
| Databáze: | OpenAIRE |
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