Prospective study using villous length morphometry as an adjunctive tool to assess modified Marsh grade in patients with coeliac disease
| Autor: | Sandhu Jashan, Suri Vijay, Vijay K Dubey |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Duodenum Biopsy Gastroenterology Coeliac disease 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Ingestion Humans In patient Prospective Studies Villous atrophy Intestinal Mucosa Prospective cohort study Grading (tumors) chemistry.chemical_classification Autoimmune disease business.industry Public Health Environmental and Occupational Health medicine.disease Gluten Celiac Disease Infectious Diseases chemistry 030220 oncology & carcinogenesis 030211 gastroenterology & hepatology business |
| Zdroj: | Tropical doctor. 51(3) |
| ISSN: | 1758-1133 |
| Popis: | Coeliac disease, an autoimmune disease, is caused by ingestion of gluten in genetically susceptible individuals. The currently used modified-Marsh grading, used to assess mucosal injury, is fraught with interobserver and intraobserver variability. The aim is to reduce this variability by villous length morphometry. Our prospective study was conducted on newly diagnosed cases of coeliac disease that were assessed by serohaematological profile, and duodenal biopsies were evaluated by modified Marsh grading. Villous length was measured in Grades 2, 3a and 3b using an eyepiece graticule lens calibrated with a stage micrometer. Severity of mucosal injury in different Marsh grades was significantly correlated to mean villous length, elevation of mean IgA tTG and drop in haemoglobin. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|