Beneficial effect of combination therapy comprising angiotensin II receptor blocker plus calcium channel blocker on plasma adiponectin levels

Autor:	Sunao Kodama, Shunichiro Sumi, Chie Ando, Hideya Niimura, Yukiko Inoue, Yoshihiro Tsuchiya, Yoshisuke Nonaka, Hidenori Urata, Keisuke Okamura, Tatsuyuki Kakuma, Kei Miyoshi, Yoshio Yamanouchi
Rok vydání:	2010
Předmět:	Male medicine.medical_specialty Angiotensin receptor Dihydropyridines Combination therapy Physiology medicine.drug_class chemistry.chemical_element Calcium channel blocker Calcium Pharmacology Benzoates Cohort Studies Internal medicine Internal Medicine medicine Humans Telmisartan Aged Retrospective Studies Sex Characteristics Adiponectin business.industry Antagonist Age Factors General Medicine Middle Aged Calcium Channel Blockers Endocrinology Blood pressure chemistry Hypertension Benzimidazoles Drug Therapy Combination Female business Angiotensin II Type 1 Receptor Blockers Azetidinecarboxylic Acid medicine.drug
Zdroj:	Clinical and experimental hypertension (New York, N.Y. : 1993). 32(1)
ISSN:	1525-6006
Popis:	The study aim was to examine the effect of combination therapy comprising angiotensin receptor blocker plus calcium antagonist on post-treatment plasma adiponectin levels compared to pretreatment levels. There was a significant gender difference in the relationship between preadiponectin level and age. In the search for contributing factors for treatment-based changes in adiponectin levels, these effects of gender and age were considered in statistical analysis. The adiponectin level in the combination therapy group was further increased compared to that in each of the monotherapy groups, despite there being no significant difference in antihypertensive effect, indicating that the combined medication provided an effect beyond that of lowering blood pressure.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::293d245f6e266ab5169c52b9c0da3a55 https://pubmed.ncbi.nlm.nih.gov/20144069 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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