The effects of prolonged CO 2 insufflation on kidney function in a rat pneumoperitoneum model

Autor: Zumrut Mine Isık Saglam, Nilgun Rukiye Erdogan, Turgut Donmez, Dogan Yildirim, Huseyin Kilincaslan, Semih Lutfi Mirapoglu, Oguzhan Sunamak, Adnan Hut
Rok vydání: 2017
Předmět:
medicine.medical_specialty
Urology
030232 urology & nephrology
Ischemia
lcsh:Medicine
Renal function
rats
Lipocalin
Gastroenterology
03 medical and health sciences
0302 clinical medicine
Pneumoperitoneum
cystatin C
Internal medicine
medicine
Original Paper
biology
business.industry
lcsh:R
Acute kidney injury
Obstetrics and Gynecology
pneumoperitoneum
neutrophil gelatinase-associated lipocalin
medicine.disease
Surgery
body regions
Yildirim D.
Donmez T.
Sunamak O.
Mirapoglu S.
Hut A.
Erdogan N. R.
Saglam Z. M. I.
Kilincaslan H.
-The effects of prolonged CO2 insufflation on kidney function in a rat pneumoperitoneum model-
VIDEOSURGERY AND OTHER MINIINVASIVE TECHNIQUES
cilt.12
ss.125-134
2017
acute kidney injury
Cystatin C
030220 oncology & carcinogenesis
biology.protein
Biomarker (medicine)
business
Splanchnic
Zdroj: Videosurgery and Other Miniinvasive Techniques, Vol 12, Iss 2, Pp 125-134 (2017)
Videosurgery and other Miniinvasive Techniques
ISSN: 1895-4588
DOI: 10.5114/wiitm.2017.67210
Popis: Introduction : Pneumoperitoneum (PP) is known to cause ischemia in kidneys and other intra-abdominal organs because of decreased splanchnic blood flow. Aim : We aimed to determine the degree of renal injury that occurs due to a PP and prolonged PP. We measured renal injury biomarkers and made a histopathological evaluation to estimate the degree of injury and assessed the correlation of biomarkers with histopathological findings. Material and methods : Twenty-one female Sprague Dawley rats were separated randomly into three groups. Group 1 was the control group and was given anesthesia for 3 h. In group 2, a PP was administered under anesthesia for 1 h. A pneumoperitoneum was administered under anesthesia to animals in group 3 for 3 h. Results : Pathological analysis showed a significant statistical difference between the 3 groups. In particular, neutrophil gelatinase-associated lipocalin (NGAL) and cystatin C (Cys C) levels at the 24th h and preoperative mean urea levels showed a significant difference between the groups. The 24th-hour NGAL level in group 3 was significantly higher than that of group 1. The preoperative Cys C level was higher in group 1 than in either group 2 or 3. Cys C was decreased significantly in group 1 and increased significantly in both groups 2 and 3. Conclusions : The increase in NGAL and Cys C levels directly correlated with the duration of PP and intra-abdominal pressure, and they are therefore good biomarkers in diagnosing acute renal injury in the early phase. Serum creatinine level is not a good biomarker in the early phase of renal injury.
Databáze: OpenAIRE
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