NMR screening approach for discovery of new 6-methylpyridinone derivatives from the marine-derived fungus Leptosphaerulina sp
| Autor: | Xiao Feng Zhu, Gong Kan Feng, Xiao Hong Chen, Wen Dan Chen, Ting Chen, Wen-Jian Lan, Chi Keung Lam, Hou-Jin Li |
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| Rok vydání: | 2017 |
| Předmět: |
South china
Chemistry(all) Stereochemistry General Chemical Engineering Fungus 01 natural sciences Single Crystal Diffraction Metabolites Marine fungus GeneralLiterature_REFERENCE(e.g. dictionaries encyclopedias glossaries) ComputingMilieux_MISCELLANEOUS biology 010405 organic chemistry Chemistry Leptosphaerulina sp Acanthaster 6-Methylpyridinone derivatives General Chemistry biology.organism_classification 0104 chemical sciences 010404 medicinal & biomolecular chemistry Leptosphaerulina Proton NMR Chemical Engineering(all) Two-dimensional nuclear magnetic resonance spectroscopy |
| Zdroj: | Arabian Journal of Chemistry. 10(2):288-294 |
| ISSN: | 1878-5352 |
| DOI: | 10.1016/j.arabjc.2015.06.015 |
| Popis: | By the method of 1 H NMR prescreening and tracing the diagnostic signals, 6-methylpyridinone derivatives, (8 R ,9 S )-dihydroisoflavipucine ( 1 ), (8 S ,9 S )-dihydroisoflavipucine ( 2 ), 3-(1-hydroxy-4-methyl-2-oxopentylidene)-6-methylpyridine-2,4(1 H ,3 H )-dione ( 3 ), 4-hydroxy-3-(2-hydroxy-4-methylpentanoyl)-6-methylpyridin-2(1 H )-one ( 4 ), 4-hydroxy-3-[(4-hydroxy-6-methyl-2-oxo-2 H -pyran-3-yl)methyl]-6-methylpyridin-2(1 H )-one ( 5 ) and a known 6-methylpyranone derivative 3,3′-methylenebis(4-hydroxy-6-methyl-2 H -pyran-2-one) ( 6 ) were isolated from the marine fungus Leptosphaerulina sp., which was collected from the starfish Acanthaster planci from the South China Sea. Compounds 2 and 3 are new compounds. Their structures were elucidated on the basis of MS, 1D and 2D NMR, and X-ray single crystal diffraction data. The absolute configurations of compounds 1 and 2 were determined by analysis on the experimental circular-dichroism spectra. |
| Databáze: | OpenAIRE |
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