Prior exposure to MK-801 sensitizes rats to ethanol-induced conditioned taste aversion
| Autor: | Jerzy Piasecki, Przemyslaw Bienkowski, Eliza Koros, Wojciech Kostowski |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Male
Ethanol Dose-Response Relationship Drug Chemistry Antagonist Central Nervous System Depressants General Medicine Pharmacology Rats Dizocilpine chemistry.chemical_compound Discrimination Psychological Anesthesia Taste medicine Taste aversion NMDA receptor Animals Conditioning Operant Aversive Stimulus Dizocilpine Maleate Rats Wistar Excitatory Amino Acid Antagonists medicine.drug |
| Zdroj: | Alcohol and alcoholism (Oxford, Oxfordshire). 33(2) |
| ISSN: | 0735-0414 |
| Popis: | Pretreatment with an uncompetitive NMDA receptor antagonist, dizocilpine (( + )MK-801; six daily injections of 0.1 or 0.2 mg/kg, i.p.) significantly enhanced subsequent 1.5 g/kg ethanol-induced conditioned taste aversion (CTA). In a control experiment, dizocilpine (0.05-0.2 mg/kg) produced only a marginal CTA. Thus, pre-exposure to low, non-aversive doses of MK-801 may sensitize rats to the aversive stimulus effects of ethanol. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|