Sex-specific associations between thyrotropin and serum lipid profiles
| Autor: | Karl Werdan, Daniel Tiller, Henri Wallaschofski, Allan Linneberg, Carsten Agger, Torben Jørgensen, Alexander Kluttig, Sabine Schipf, Joachim Thiery, Till Ittermann, Christa Meisinger, Karin Halina Greiser, Katrin Burkhardt, Henry Völzke, Matthias Nauck |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Adult
Male endocrine system medicine.medical_specialty Cross-sectional study Endocrinology Diabetes and Metabolism Population Thyrotropin Reference range White People chemistry.chemical_compound Young Adult Endocrinology Reference Values Internal medicine medicine Humans Young adult education Aged Aged 80 and over education.field_of_study Triglyceride Cholesterol business.industry Middle Aged Sex specific Lipids Cross-Sectional Studies chemistry lipids (amino acids peptides and proteins) Female business hormones hormone substitutes and hormone antagonists Lipoprotein |
| Zdroj: | Thyroid : official journal of the American Thyroid Association. 24(3) |
| ISSN: | 1557-9077 |
| Popis: | Population-based studies investigating the sex-specific association between thyrotropin (TSH) levels and serum lipid concentrations are scarce. We examined the association between TSH and total cholesterol, low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, and triglycerides in men and women from the general population. Furthermore, the association with TSH outside and within the reference range and lipid levels was studied.Individual data of 13,571 men and women without lipid medication of four population-based studies conducted in Western European adults were pooled for cross-sectional analyses. The association between TSH levels and lipid concentrations were analyzed by calculating sex-specific multivariable median regression models.In the pooled population, serum TSH levels were significantly positively associated with triglyceride values in men and with total cholesterol, LDL cholesterol, and triglyceride values in women. In the pooled male population, low serum TSH levels (3.0 mIU/L) were significantly associated with lower total cholesterol, while high serum TSH levels (≥ 3.0 mIU/L) were associated with higher triglyceride values. In the pooled female population, low serum TSH levels were significantly associated with lower total cholesterol, LDL cholesterol, and HDL cholesterol. High TSH levels were associated with higher total cholesterol and LDL cholesterol in the pooled female population. In both sexes, serum TSH levels within the reference range (0.3-3.0 mIU/L) were significantly positively associated with triglyceride concentrations.Increasing levels of TSH were associated with a less favorable lipid profile in both men and women from the general population. In both sexes, TSH levels within the reference range were significantly positively associated with triglyceride concentrations. |
| Databáze: | OpenAIRE |
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