Synthesis and activity of selective MMP inhibitors with an aryl backbone

Autor:	Anna M. Stevens, Shashi Rao, Louis J. Bedell, Huey-Sheng Shieh, Clara I. Villamil, Grace E. Munie, Thomas E. Barta, Roderick A. Stegeman, Gary A. De Crescenzo, Daniel P. Becker, Joseph J. McDonald
Rok vydání:	2001
Předmět:	Models Molecular Stereochemistry Clinical Biochemistry Pharmaceutical Science Ether Antineoplastic Agents Matrix Metalloproteinase Inhibitors Crystallography X-Ray Hydroxamic Acids Biochemistry Chemical synthesis chemistry.chemical_compound Inhibitory Concentration 50 Structure-Activity Relationship Drug Discovery Matrix Metalloproteinase 13 Humans Collagenases Enzyme Inhibitors Molecular Biology chemistry.chemical_classification Hydroxamic acid integumentary system biology Aryl Organic Chemistry Biological activity Sulfonamide Enzyme chemistry Enzyme inhibitor biology.protein Molecular Medicine Matrix Metalloproteinase 2 Matrix Metalloproteinase 1
Zdroj:	Bioorganicmedicinal chemistry letters. 10(24)
ISSN:	0960-894X
Popis:	A series of novel, MMP-1 sparing arylhydroxamate sulfonamides with activity against MMP-2 and -13 is described.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2936c0c3b342654db058d53b317edd7a https://pubmed.ncbi.nlm.nih.gov/11133099 Zobrazit plný text záznamu Full Text from ScienceDirect