CARDIOVASCULAR RISK FACTORS IN ADOLESCENTS: ROLE OF INSULIN RESISTANCE AND OBESITY
| Autor: | Sergio Sánchez-Enríquez, Blanca-Estela Bastidas-Ramirez, Edgar-Alfonso Rivera-Leon, J Lopez-Sandoval, M R Garcia-Garcia, Mercedes González-Hita |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Endocrinology Diabetes and Metabolism medicine.medical_treatment Population Childhood obesity 03 medical and health sciences Endocrinology Insulin resistance Diabetes mellitus Internal medicine Medicine education education.field_of_study Adiponectin Endocrine and Autonomic Systems business.industry Endocrine Care Insulin nutritional and metabolic diseases medicine.disease Obesity 030104 developmental biology business Dyslipidemia |
| Popis: | Introduction Childhood obesity is a public health problem characterized by early insulin resistance (IR), inflammation, and oxidative stress. The presence of an uninterrupted low-grade inflammatory state impairs metabolic and cardiovascular health. The population is particularly susceptible to develop metabolic disorders related to increased body fat. Methods Eighty-three adolescents were recruited and grouped according to HOMA-IR and BMI in either with or without IR and obese or normal-weight respectively. Anthropometric, biochemical, immunological and hormonal variables were determined. Transverse Analytical Study. Results Obesity, dyslipidemia, IL-6, and C-reactive protein were significantly higher in the IR group than in the non-IR group. Obese adolescents showed increased insulin levels, HOMA-IR, inflammatory markers, and triglycerides; while having lower HDL-C, and adiponectin when compared to normal-weight adolescents. As expected, obesity-related anthropometric markers positively correlated with IR and inflammatory markers while negatively correlated with adiponectin levels. Conclusions Early IR, subclinical inflammation, dyslipidemia, and hypoadiponectinemia characterize obesity in adolescents. These factors may increase the risk of future coronary heart disease (CHD) and diabetes mellitus development (DM) in early adulthood. |
| Databáze: | OpenAIRE |
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