Host-bacteria interactions in foreign body infections
| Autor: | Patrice Francois, Timothy J. Foster, Pierre Vaudaux, Daniel Pablo Lew |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 1996 |
| Předmět: |
Microbiology (medical)
Staphylococcus aureus Prosthesis-Related Infections Epidemiology Staphylococcal infections Fibrinogen medicine.disease_cause Fibrin Bacterial Adhesion Microbiology Catheters Indwelling/ microbiology Catheters Indwelling Bacterial Proteins Prostheses and Implants/ microbiology medicine Animals Humans Prosthesis-Related Infection Adhesins Bacterial ddc:616 Cross Infection biology Prostheses and Implants Staphylococcal Infections medicine.disease biology.organism_classification Fibronectin Bacterial adhesin Infectious Diseases Bacterial Adhesion/physiology Immunology biology.protein Staphylococcus aureus/ pathogenicity Carrier Proteins Bacteria medicine.drug Bacterial Outer Membrane Proteins |
| Zdroj: | Infection Control and Hospital Epidemiology, Vol. 17, No 8 (1996) pp. 514-520 |
| ISSN: | 0899-823X |
| Popis: | Persistent staphylococcal infections are a major medical problem, especially when they occur on implanted materials or intravascular catheters. This review describes some of the recently discovered molecular mechanisms ofStaphylococcus aureusattachment to host proteins coating biomedical implants. These interactions involve specific surface proteins, called bacterial adhesins, that recognize specific domains of host proteins deposited on indwelling devices, such as fibronectin, fibrinogen, or fibrin. Elucidation of molecular mechanisms ofS aureusadhesion to the different host proteins may lead to the development of specific inhibitors blocking attachment ofS aureus, which may decrease the risk of bacterial colonization of indwelling devices. |
| Databáze: | OpenAIRE |
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