The triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio as a predictor of insulin resistance but not of β cell function in a Chinese population with different glucose tolerance status
| Autor: | Wei Li, Linbo Feng, Xuefeng Zhao, Fan Ping, Xiangli Cui, Yuxiu Li, Shuli He, Lixin Zhu, Meicen Zhou |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Blood Glucose
Male medicine.medical_treatment Endocrinology Diabetes and Metabolism Clinical Biochemistry 030204 cardiovascular system & hematology chemistry.chemical_compound 0302 clinical medicine High-density lipoprotein Endocrinology Insulin-Secreting Cells Glucose tolerance status Insulin Glucose tolerance test education.field_of_study medicine.diagnostic_test Fasting Middle Aged β cell function Area Under Curve lipids (amino acids peptides and proteins) Female Adult medicine.medical_specialty Lipid ratios Population 030209 endocrinology & metabolism Biology Diagnosis Differential Prediabetic State 03 medical and health sciences Insulin resistance Asian People Internal medicine Diabetes mellitus medicine Humans education Triglycerides Aged Biochemistry medical Triglyceride Cholesterol Research Biochemistry (medical) Cholesterol HDL nutritional and metabolic diseases Cholesterol LDL Glucose Tolerance Test medicine.disease Cross-Sectional Studies chemistry Diabetes Mellitus Type 2 ROC Curve Biomarkers |
| Zdroj: | Lipids in Health and Disease |
| ISSN: | 1476-511X |
| Popis: | Background Triglyceride/high-density lipoprotein-cholesterol (TG/HDL-C) ratio was a surrogate marker of IR; however, the relationship of TG/HDL-C with IR might vary by ethnicity. This study aims to investigate whether lipid ratios-TG/HDL-C, cholesterol/high-density lipoprotein-cholesterol (TC/HDL-C) ratio, low-density lipoprotein-cholesterol/high-density lipoprotein-cholesterol (LDL-C/HDL-C)) could be potential clinical markers of insulin resistance (IR) and β cell function and further to explore the optimal cut-offs in a Chinese population with different levels of glucose tolerance. Methods Four hundred seventy-nine subjects without a history of diabetes underwent a 75 g 2 h Oral Glucose Tolerance Test (OGTT). New-onset diabetes (n = 101), pre-diabetes (n = 186), and normal glucose tolerance (n = 192) were screened. IR was defined by HOMA-IR > 2.69. Based on indices (HOMA-β, early-phase disposition index [DI30], (ΔIns30/ΔGlu30)/HOMA-IR and total-phase index [DI120]) that indicated different phases of insulin secretion, the subjects were divided into two groups, and the lower group was defined as having inadequate β cell compensation. Logistic regression models and accurate estimates of the areas under receiver operating characteristic curves (AUROC) were obtained. Results In all of the subjects, TG/HDL, TC/HDL-C, LDL-C/HDL-C, and TG were significantly associated with IR. The AUROCs of TG/HDL-C and TG were 0.71 (95 % CI: 0.66–0.75) and 0.71 (95 % CI: 0.65–0.75), respectively. The optimal cut-offs of TG/HDL-C and TG for IR diagnosis were 1.11 and 1.33 mmol/L, respectively. The AUROCs of TC/HDL-C and LDL-C/HDL-C were 0.66 and 0.65, respectively, but they were not acceptable for IR diagnosis. TG/HDL-C,LDL-C/HDL-C and TG were significantly associated with HOMA-β, but AUROCs were less than 0.50; therefore, the lipid ratios could not be predictors of basal β cell dysfunction. None of the lipid ratios was associated with early-phase insulin secretion. Only TG/HDL-C and TG were significantly correlated with total-phase insulin secretion, but they also were not acceptable predictors of total-phase insulin secretion (0.60 |
| Databáze: | OpenAIRE |
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