Prevalence of multidrug-resistant organisms in nursing homes in Belgium in 2015
| Autor: | Youri Glupczynski, Te-Din Huang, Béatrice Jans, Katrien Latour, Audrey Noël, Olivier Denis, Pierre Bogaerts, Katherine Loens, Didier Schoevaerdts, Claire Nonhoff, Magali Dodémont, Catherine Berhin, Margareta Ieven, Boudewijn Catry |
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| Přispěvatelé: | UCL - SSS/IREC/MONT - Pôle Mont Godinne, UCL - (MGD) Laboratoire de biologie clinique, UCL - (MGD) Service de médecine gériatrique |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Male
Meticillin Epidemiology Nosocomial Infections Staphylococcus Psychologie appliquée Drug resistance COLONIZATION Klebsiella Pneumoniae 0302 clinical medicine Belgium Antibiotics Risk Factors Klebsiella Drug Resistance Multiple Bacterial Antimicrobial stewardship Infection control EPIDEMIOLOGY 030212 general & internal medicine Pathology and laboratory medicine Aged 80 and over 0303 health sciences Antiinfective agent Multidisciplinary Antimicrobials Enterobacteriaceae Infections Drugs Sciences bio-médicales et agricoles Medical microbiology Middle Aged Staphylococcal Infections Hospitals Anti-Bacterial Agents Multidisciplinary Sciences CARBAPENEMASE-PRODUCING ENTEROBACTERIACEAE Infectious Diseases CARRIAGE BACTERIA Vancomycin Medicine Science & Technology - Other Topics Female Pathogens Engineering sciences. Technology Biologie medicine.drug RESIDENTS Research Article Adult Methicillin-Resistant Staphylococcus aureus medicine.medical_specialty Staphylococcus aureus Science Microbial Sensitivity Tests Microbiology Vancomycin-Resistant Enterococci 03 medical and health sciences Enterobacteriaceae Internal medicine Microbial Control medicine Humans LACTAMASE-PRODUCING ENTEROBACTERIACEAE STAPHYLOCOCCUS-AUREUS Aged Medicine and health sciences Pharmacology Science & Technology Biology and life sciences Bacteria 030306 microbiology business.industry Organisms Rectum biochemical phenomena metabolism and nutrition bacterial infections and mycoses Trimethoprim Microbial pathogens Nursing Homes Health Care Carriage Cross-Sectional Studies Health Care Facilities TERM-CARE FACILITIES Medical Risk Factors RISK-FACTORS Bacterial pathogens business |
| Zdroj: | PloS one, Vol. 14, no. 3, p. e0214327 [1-18] (2019) PLoS ONE PloS one, 14 (3 PLoS ONE, Vol 14, Iss 3, p e0214327 (2019) |
| ISSN: | 1932-6203 |
| Popis: | Objectives Following two studies conducted in 2005 and 2011, a third prevalence survey of multidrug-resistant microorganisms (MDRO) was organised in Belgian nursing homes (NHs) using a similar methodology. The aim was to measure the prevalence of carriage of methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant enterococci (VRE), extended-spectrum β-lactamase producing Enterobacteriaceae (ESBLE) and carbapenemase-producing Enterobacteriaceae (CPE) in NH residents. Risk factors for MDRO carriage were also explored. Methods Up to 51 randomly selected residents per NH were screened for MDRO carriage by trained local nurses between June and October 2015. Rectal swabs were cultured for ESBLE, CPE and VRE, while pooled samples of nose, throat and perineum and chronic wound swabs were obtained for culture of MRSA. Antimicrobial susceptibility testing, molecular detection of resistance genes and strain genotyping were performed. Significant risk factors for MDRO colonization MDRO was determined by univariate and multivariable analysis. Results Overall, 1447 residents from 29 NHs were enrolled. The mean weighted prevalence of ESBLE and MRSA colonization was 11.3% and 9.0%, respectively. Co-colonization occurred in 1.8% of the residents. VRE and CPE carriage were identified in only one resident each. Impaired mobility and recent treatment with fluoroquinolones or with combinations of sulphonamides and trimethoprim were identified as risk factors for ESBLE carriage, while for MRSA these were previous MRSA carriage/infection, a stay in several different hospital wards during the past year, and a recent treatment with nitrofuran derivatives. Current antacid use was a predictor for both ESBL and MRSA carriage. Conclusions In line with the evolution of MRSA and ESBL colonization/infection in hospitals, a decline in MRSA carriage and an increase in ESBLE prevalence was seen in Belgian NHs between 2005 and 2015. These results show that a systemic approach, including surveillance and enhancement of infection control and antimicrobial stewardship programs is needed in both acute and chronic care facilities. SCOPUS: ar.j info:eu-repo/semantics/published |
| Databáze: | OpenAIRE |
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