Provider recommendations for patient-reported muscle symptoms on statin therapy: Insights from the Understanding Statin Use in America and Gaps in Patient Education survey

Autor: Jerome D. Cohen, Eliot A. Brinton, Kevin C. Maki, Terry A. Jacobson, Abdullah Khan
Rok vydání: 2018
Předmět:
Male
myalgia
medicine.medical_specialty
Statin
Ubiquinone
medicine.drug_class
Endocrinology
Diabetes and Metabolism
Hypercholesterolemia
030204 cardiovascular system & hematology
High cholesterol
03 medical and health sciences
0302 clinical medicine
Surveys and Questionnaires
Patient experience
Internal Medicine
medicine
Humans
cardiovascular diseases
030212 general & internal medicine
Vitamin D
Intensive care medicine
Aged
Internet
Nutrition and Dietetics
business.industry
nutritional and metabolic diseases
Muscle weakness
Myalgia
Middle Aged
Statin treatment
medicine.disease
Discontinuation
Dietary Supplements
Physical therapy
Female
lipids (amino acids
peptides
and proteins)
Self Report
Statin therapy
Americas
Hydroxymethylglutaryl-CoA Reductase Inhibitors
medicine.symptom
Cardiology and Cardiovascular Medicine
business
Zdroj: Journal of Clinical Lipidology. 12:78-88
ISSN: 1933-2874
DOI: 10.1016/j.jacl.2017.09.006
Popis: Statin-associated muscle symptoms are reported by 10% to 29% of patients in clinical practice and are a major determinant of statin nonadherence, discontinuation, and switching. Little is known about what advice patients receive from their providers when dealing with these symptoms.The objective of the study was to assess patient's reports of provider advice when experiencing new or worsened muscle symptoms while taking a statin.Data were analyzed from the Understanding Statin Use in America and Gaps in Education survey, a self-administered internet-based survey of 10,138 adults with a reported history of high cholesterol and statin use.Of the respondents, 60% of former statin users (n = 1220) reported ever experiencing new or worsened muscle pain on a statin, in contrast to 25% of current users (n = 8918; P .001). Former statin users reported stopping more statins because of muscle symptoms (mean ± standard deviation, 2.2 ± 1.7) compared with current users (mean 1.6 ± 1.5, P .0001). For those with muscle-related symptoms while on a statin, participants reported that providers most often suggested switching to another statin (33.8%), stopping the statin (15.9%), continuing the statin with further monitoring of muscle symptoms (12.2%), reducing the statin dose (9.8%), or getting a blood test for signs of muscle damage (9.2%). A lower percentage were advised to add either vitamin D (7.0%) or coenzyme Q10 (5.8%), or to switch to nonstatin therapy (6.1%) or red yeast rice (2.6%).This study highlights patient experience with statin-associated muscle symptoms and the strategies recommended by providers in managing these symptoms. More research is needed to develop patient-centric and evidence-based approaches to managing statin-associated muscle symptoms, which is especially important in light of recent data showing increased cardiovascular risk among those who discontinue statin therapy.
Databáze: OpenAIRE
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