DIFFERENTIAL EFFECTS OF THE BENZODIAZEPINE ANTAGONISTRO 15-1788 AFTER 'GENERAL ANAESTHETIC' DOSES OF BENZODIAZEPINES IN MICE
| Autor: | H.J. Little, A.R. Bichard |
|---|---|
| Rok vydání: | 1984 |
| Předmět: |
Flumazenil
Male medicine.drug_class Flurazepam Midazolam Convulsants Mice Inbred Strains Anesthesia General Pharmacology Chlordiazepoxide Benzodiazepines Mice Reflex medicine Animals General anaesthetic Anesthetics Benzodiazepinones Benzodiazepine Diazepam business.industry Anesthesiology and Pain Medicine Anti-Anxiety Agents Anesthesia Righting reflex business medicine.drug |
| Zdroj: | British Journal of Anaesthesia. 56:1153-1160 |
| ISSN: | 0007-0912 |
| Popis: | The effects of the benzodiazepine antagonist Ro 15-1788 20 mg kg-1 after "general anaesthetic" doses of several benzodiazepines were studied in mice, in order to determine if the effects of the latter were attributable to an action at benzodiazepine receptors. Male CDI mice were used and the end-points for anaesthesia were loss of the righting reflex and loss of the foot pinch reflex. The effects of midazolam, and to a lesser extent those of chlordiazepoxide and of diazepam on these reflexes, were antagonized partially by Ro 15-1788. When the antagonist was given after high doses of flurazepam, convulsions were produced. Calculation of the likely membrane concentrations of the benzodiazepines showed that these fitted the lipid solubility correlation for general anaesthesia. Ro 15-1788 did not decrease the lethal effects of the benzodiazepines. With flurazepam, chlordiazepoxide and diazepam it caused signs of hyperexcitability, which in the case of flurazepam led to the death of the animals. |
| Databáze: | OpenAIRE |
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