Human beta-defensin 3 contributes to the carcinogenesis of cervical cancer via activation of NF-κB signaling
| Autor: | Dan Xu, Bing Zhang, Yongping Shao, Wei Zhang, Chongbing Liao, Ying Chang, Weijia Wang |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
beta-Defensins cervical cancer Uterine Cervical Neoplasms Antineoplastic Agents Apoptosis medicine.disease_cause Mice 03 medical and health sciences 0302 clinical medicine Cell Movement Cell Line Tumor medicine Animals Humans Cervical cancer Cell growth business.industry Cell Cycle NF-kappa B Cell migration Cell cycle medicine.disease Xenograft Model Antitumor Assays Gene Expression Regulation Neoplastic Disease Models Animal Cell Transformation Neoplastic 030104 developmental biology Beta defensin Oncology 030220 oncology & carcinogenesis Immunology Cancer research Female human beta-defensin 3 Signal transduction Carcinogenesis business carcinogenesis Biomarkers Signal Transduction Research Paper |
| Zdroj: | Oncotarget |
| ISSN: | 1949-2553 |
| DOI: | 10.18632/oncotarget.12426 |
| Popis: | // Dan Xu 1, * , Bing Zhang 1, * , Chongbing Liao 2 , Wei Zhang 1 , Weijia Wang 2 , Ying Chang 1, 2 , Yongping Shao 1, 2 1 Key Laboratory of Biomedical Information Engineering of the Ministry of Education, Department of Biological Science and Engineering, School of Life Science and Technology, Xi’an Jiaotong University, Xi’an, Shaanxi, China 2 Center for Translational Medicine, Frontier Institute of Science and Technology, Xi'an Jiaotong University, Xi'an, Shaanxi, China * These authors have contributed equally to this work Correspondence to: Yongping Shao, email: yongping.shao@xjtu.edu.cn Keywords: human beta-defensin 3, cervical cancer, carcinogenesis Received: June 30, 2016 Accepted: September 21, 2016 Published: October 04, 2016 ABSTRACT Human beta-defensin 3 (hBD3), an antimicrobial peptide (AMP) expressed in epithelium in response to various stimulations including human papillomavirus infection, has recently been found to be overexpressed in head and neck cancers and exhibit tumorigenic activities. However, the role of hBD3 in cervical cancer remains to be investigated. In this study, we showed by immunohistochemistry that hBD3 expression was elevated in cervical cancer samples of different stages versus the normal tissue, and was positively correlated with the progression of the disease. Overexpression of hBD3 in cervical cancer cell lines promoted cell proliferation by accelerating G1/S progression and enhanced cell migration and invasion in vitro . These oncogenic effects of hBD3 were associated with activation of NF-κB signaling. Using a mouse xenograft model, we further demonstrated that hBD3 overexpression promoted the growth of cervical cancer cells in vivo . Our results suggested that hBD3 is involved in the carcinogenesis and development of cervical cancer, and may serve as a biomarker or therapeutic target of this disease. |
| Databáze: | OpenAIRE |
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