Effects of Trans-Cinnamaldehyde on Reperfused Ischemic Skeletal Muscle and the Relationship to Laminin
| Autor: | Senay Balci, Gülsen Bayrak, Ebru Balli, Belgin Buyukakilli, Esra Pekoglu, Burak Çimen, Cagatay Han Turkseven |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Pathology
medicine.medical_specialty Cinnamaldehyde Rats Sprague-Dawley 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Laminin Ischemia Medicine Animals Acrolein Muscle Skeletal Tourniquet biology business.industry Skeletal muscle Compartment (chemistry) Rats medicine.anatomical_structure chemistry 030220 oncology & carcinogenesis Reperfusion Injury biology.protein Vascular trauma 030211 gastroenterology & hepatology Surgery business |
| Zdroj: | Journal of investigative surgery : the official journal of the Academy of Surgical Research. 34(12) |
| ISSN: | 1521-0553 |
| Popis: | Ischemia-reperfusion (I-R) injury is a serious problem caused by vascular trauma, tourniquet use and/or compartment syndrome. Studies have reported that skeletal muscle function is impaired due to the lower extremity I-R injury. There are insufficient studies on the treatment methods used for the recovery of dysfunction. This study is designed to investigate the effects of trans-cinnamaldehyde (TCA), a volatile oil of cinnamon structure, on the contractile dysfunction due to I-R injury of rat extensor-digitorum-longus (EDL) muscle.Sprague-Dawley rats were randomly divided into three groups. Except for the animals in the control group, all animals received saline (3-ml/kg) or TCA solution (30-mg/kg) which was administered orally three times with an 8-h interval before ischemia. After 24-hours, experimental groups were subjected to 3-h of lower extremity ischemia followed by 5-h reperfusion period. Then, the compound muscle action potential (CMAP) and mechanical activity of muscle were recorded using the standard electro-biophysical techniques.There was a decrease in the maximum contractile force in I-R group compared to the control group (We concluded that TCA has a potential protective effect with antioxidant effects against I-R injury and may maintain laminin levels. |
| Databáze: | OpenAIRE |
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