Unsupervised Learning in Detection of Gene Transfer

Autor: Olga Zhaxybayeva, Johann Peter Gogarten, Lutz Hamel, Maria Poptsova, Neha Nahar
Jazyk: angličtina
Rok vydání: 2008
Předmět:
Halobacterium salinarum
0106 biological sciences
Gene Transfer
Horizontal
Article Subject
lcsh:Biotechnology
Health
Toxicology and Mutagenesis
lcsh:Medicine
Genomics
Biology
010603 evolutionary biology
01 natural sciences
Genome
Genes
Archaeal
Evolution
Molecular
03 medical and health sciences
Gene Frequency
Species Specificity
Artificial Intelligence
Phylogenetics
lcsh:TP248.13-248.65
Sequence Homology
Nucleic Acid
Genetics
Cluster Analysis
Selection
Genetic
Molecular Biology
Phylogeny
Organism
030304 developmental biology
0303 health sciences
Models
Genetic
Phylogenetic tree
lcsh:R
Computational Biology
General Medicine
Evolutionary biology
Archaeoglobus fulgidus
Tree rearrangement
Methanosarcina
Horizontal gene transfer
RNA
Molecular Medicine
Unsupervised learning
Research Article
Biotechnology
Zdroj: Journal of Biomedicine and Biotechnology
Journal of Biomedicine and Biotechnology, Vol 2008 (2008)
ISSN: 1110-7243
DOI: 10.1155/2008/472719
Popis: The tree representation as a model for organismal evolution has been in use since before Darwin. However, with the recent unprecedented access to biomolecular data, it has been discovered that, especially in the microbial world, individual genes making up the genome of an organism give rise to different and sometimes conflicting evolutionary tree topologies. This discovery calls into question the notion of a single evolutionary tree for an organism and gives rise to the notion of an evolutionary consensus tree based on the evolutionary patterns of the majority of genes in a genome embedded in a network of gene histories. Here, we discuss an approach to the analysis of genomic data of multiple genomes using bipartition spectral analysis and unsupervised learning. An interesting observation is that genes within genomes that have evolutionary tree topologies, which are in substantial conflict with the evolutionary consensus tree of an organism, point to possible horizontal gene transfer events which often delineate significant evolutionary events.
Databáze: OpenAIRE
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