Hyperferritinemia as a Diagnostic Marker for Severe Fever with Thrombocytopenia Syndrome
| Autor: | Uh Jin Kim, Seung-Ji Kang, Hee-Chang Jang, Sook-In Jung, Seong Eun Kim, Kyung-Hwa Park, Tae Hoon Oh, Ban-Suk Kim |
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| Rok vydání: | 2017 |
| Předmět: |
Calcitonin
Male 0301 basic medicine medicine.medical_specialty Article Subject Clinical Biochemistry Fibrinogen Gastroenterology Procalcitonin 03 medical and health sciences 0302 clinical medicine Internal medicine White blood cell Genetics medicine Humans 030212 general & internal medicine Molecular Biology Aged Aged 80 and over lcsh:R5-920 business.industry Biochemistry (medical) Case-control study Diagnostic marker Syndrome General Medicine Middle Aged medicine.disease Thrombocytopenia Severe fever with thrombocytopenia syndrome C-Reactive Protein Phlebotomus Fever 030104 developmental biology medicine.anatomical_structure Case-Control Studies Bacteremia Ferritins Immunology Female Viral disease lcsh:Medicine (General) business Biomarkers Research Article medicine.drug |
| Zdroj: | Disease Markers Disease Markers, Vol 2017 (2017) |
| ISSN: | 1875-8630 0278-0240 |
| DOI: | 10.1155/2017/6727184 |
| Popis: | Severe fever with thrombocytopenia syndrome (SFTS) is an emerging viral disease in East Asia with high mortality. Few studies have examined markers that suggest SFTS in febrile patients. To determine useful biochemical markers for SFTS, patients aged 18 years or older with SFTS or microbiologically confirmed community-onset bacteremia with thrombocytopenia (BT) at presentation between June 2013 and December 2015 were included from two tertiary university hospitals in Republic of Korea retrospectively. Eleven patients with SFTS and 62 patients with bacteremia and thrombocytopenia were identified in the study period. Age and sex did not show significant difference among two groups. Fever was more commonly observed but comorbidities were less common in SFTS than in BT (P<0.05, each). The areas under the curves of serum ferritin, C-reactive protein, white blood cell count, serum procalcitonin, and fibrinogen were above 0.9, indicating the discriminative power of these biomarkers (1.000, 0.991, 0.963, 0.931, and 0.934, resp., allP<0.05). The optimal cutoff value of serum ferritin was 3,822 ng/mL in this study. These results suggest that hyperferritinemia is a typical laboratory feature of SFTS, and the serum ferritin level can be used as a marker for clinicians suspecting SFTS. |
| Databáze: | OpenAIRE |
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